N-(4-chlorocarbonylphenyl)-6-bromo-3-chlorobenzo[b]thiophene-2-carboxamide

Base Information

• Chemical Name: N-(4-chlorocarbonylphenyl)-6-bromo-3-chlorobenzo[b]thiophene-2-carboxamide
• CAS No.: 1381771-29-4
• Molecular Formula: C₁₆H₈BrCl₂NO₂S
• Molecular Weight: 429.121

Synonyms:N-(4-chlorocarbonylphenyl)-6-bromo-3-chlorobenzo[b]thiophene-2-carboxamide

Chemical Property of N-(4-chlorocarbonylphenyl)-6-bromo-3-chlorobenzo[b]thiophene-2-carboxamide

Chemical Property:

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Technology Process of N-(4-chlorocarbonylphenyl)-6-bromo-3-chlorobenzo[b]thiophene-2-carboxamide

There total 3 articles about N-(4-chlorocarbonylphenyl)-6-bromo-3-chlorobenzo[b]thiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N-(4-carboxyphenyl)-6-bromo-3-chlorobenzo[b]thiophene-2-carboxamide (1381771-24-9) → N-(4-chlorocarbonylphenyl)-6-bromo-3-chlorobenzo[b]thiophene-2-carboxamide (1381771-29-4)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In toluene; for 18h; Reflux;

DOI:10.1021/jm300505h

Reference yield:

6-bromo-3-chlorobenzothiophene-2-carboxylic acid chloride (75212-27-0) → N-(4-chlorocarbonylphenyl)-6-bromo-3-chlorobenzo[b]thiophene-2-carboxamide (1381771-29-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran; toluene / 3 h / 130 °C

2: thionyl chloride; N,N-dimethyl-formamide / toluene / 18 h / Reflux

With thionyl chloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; toluene;

DOI:10.1021/jm300505h

Reference yield:

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → N-(4-chlorocarbonylphenyl)-6-bromo-3-chlorobenzo[b]thiophene-2-carboxamide (1381771-29-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran; toluene / 3 h / 130 °C

2: thionyl chloride; N,N-dimethyl-formamide / toluene / 18 h / Reflux

With thionyl chloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; toluene;

DOI:10.1021/jm300505h

upstream raw materials:

N-(4-carboxyphenyl)-6-bromo-3-chlorobenzo[b]thiophene-2-carboxamide

6-bromo-3-chlorobenzothiophene-2-carboxylic acid chloride

4-amino-benzoic acid

Downstream raw materials:

6-bromo-2-{N-[4-N-(3-dimethylamino)propyl]carbamoyl}-3-chlorobenzo[b]thiophene anilide hydrochloride

6-bromo-2-{N-[4-N-(3-dimethylamino)propyl]carbamoyl}-3-chlorobenzo[b]thiophene anilide

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