3-((4-(methylamino)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-yl)amino)-N-(2-(trifluoromethyl)benzyl)cyclohexane-1-carboxamide

Base Information

• Chemical Name: 3-((4-(methylamino)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-yl)amino)-N-(2-(trifluoromethyl)benzyl)cyclohexane-1-carboxamide
• CAS No.: 1050685-11-4
• Molecular Formula: C₂₄H₃₃F₃N₈O
• Molecular Weight: 506.574
• Mol file: 1050685-11-4.mol

Synonyms:3-((4-(methylamino)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-yl)amino)-N-(2-(trifluoromethyl)benzyl)cyclohexane-1-carboxamide

Chemical Property of 3-((4-(methylamino)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-yl)amino)-N-(2-(trifluoromethyl)benzyl)cyclohexane-1-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-((4-(methylamino)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-yl)amino)-N-(2-(trifluoromethyl)benzyl)cyclohexane-1-carboxamide

There total 4 articles about 3-((4-(methylamino)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-yl)amino)-N-(2-(trifluoromethyl)benzyl)cyclohexane-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 1.8%

4-chloro-N-methyl-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-amine (1050685-08-9) + 3-amino-N-(2-(trifluoromethyl)benzyl)cyclohexanecarboxamide trifluoroacetate (1050685-13-6) → 3-((4-(methylamino)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-yl)amino)-N-(2-(trifluoromethyl)benzyl)cyclohexane-1-carboxamide (1050685-11-4)

Guidance literature:

With sodium hydroxide; In water; acetonitrile; at 80 ℃; for 16h; pH=9 - 10;

Reference yield:

4-chloro-N-methyl-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-amine (1050685-08-9) + 3-amino-N-(2-(trifluoromethyl)benzyl)cyclohexanecarboxamide (1050685-12-5) → 3-((4-(methylamino)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-yl)amino)-N-(2-(trifluoromethyl)benzyl)cyclohexane-1-carboxamide (1050685-11-4)

Guidance literature:

With sodium hydroxide; In water; acetonitrile; at 80 ℃; for 16h; pH=9 - 10;

DOI:10.1016/j.bmc.2021.116216

Reference yield:

1-methyl-piperazine (109-01-3) → 3-((4-(methylamino)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-yl)amino)-N-(2-(trifluoromethyl)benzyl)cyclohexane-1-carboxamide (1050685-11-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / acetonitrile; water / 0.25 h / 0 °C

2: sodium hydroxide / acetonitrile; water / 16 h / 80 °C / pH 9 - 10

With sodium hydroxide; In water; acetonitrile;

DOI:10.1016/j.bmc.2021.116216

upstream raw materials:

4-chloro-N-methyl-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-amine

3-amino-N-(2-(trifluoromethyl)benzyl)cyclohexanecarboxamide trifluoroacetate

o-trifluoromethylbenzylamine

3-[(tert-butoxycarbonyl)amino]cyclo-hexanecarboxylic acid