(S)-4-[3-(trifluoromethyl)phenethyl]-1-[6-(aminomethyl)-1,2,3,4-tetrahydronaphthalen-2-yl]piperazin-2-one

Base Information

Chemical Name:(S)-4-[3-(trifluoromethyl)phenethyl]-1-[6-(aminomethyl)-1,2,3,4-tetrahydronaphthalen-2-yl]piperazin-2-one
CAS No.:928675-01-8
Molecular Formula:C₂₄H₂₈F₃N₃O
Molecular Weight:431.501
Hs Code.:

Synonyms:(S)-4-[3-(trifluoromethyl)phenethyl]-1-[6-(aminomethyl)-1,2,3,4-tetrahydronaphthalen-2-yl]piperazin-2-one

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Chemical Property of (S)-4-[3-(trifluoromethyl)phenethyl]-1-[6-(aminomethyl)-1,2,3,4-tetrahydronaphthalen-2-yl]piperazin-2-one

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Technology Process of (S)-4-[3-(trifluoromethyl)phenethyl]-1-[6-(aminomethyl)-1,2,3,4-tetrahydronaphthalen-2-yl]piperazin-2-one

There total 7 articles about (S)-4-[3-(trifluoromethyl)phenethyl]-1-[6-(aminomethyl)-1,2,3,4-tetrahydronaphthalen-2-yl]piperazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 928675-00-7
(S)-6-{4-[3-(trifluoromethyl)phenethyl]-2-oxopiperazin-1-yl}-5,6,7,8-tetrahydronaphthalene-2-carbonitrile

: 928675-01-8
(S)-4-[3-(trifluoromethyl)phenethyl]-1-[6-(aminomethyl)-1,2,3,4-tetrahydronaphthalen-2-yl]piperazin-2-one

Guidance literature:: With ammonia; hydrogen; nickel; In water; N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1016/j.bmc.2006.12.028

Reference yield:

: (S)-6-amino-5,6,7,8-tetrahydronaphthalene-2-carbonitrile hydrochloride

: 928675-01-8
(S)-4-[3-(trifluoromethyl)phenethyl]-1-[6-(aminomethyl)-1,2,3,4-tetrahydronaphthalen-2-yl]piperazin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / sodium iodide; ethyldiisopropylamine / acetonitrile; dimethylformamide / 0.5 h / 130 °C / microwave irradiation

2: hydrogen; ammonia / Raney nickel / dimethylformamide; H₂O / 16 h / 20 °C

With ammonia; hydrogen; N-ethyl-N,N-diisopropylamine; sodium iodide; nickel; In water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2006.12.028

Reference yield:

: [2-(3-trifluoromethyl-phenyl)-ethylamino]-acetic acid methyl ester

: 928675-01-8
(S)-4-[3-(trifluoromethyl)phenethyl]-1-[6-(aminomethyl)-1,2,3,4-tetrahydronaphthalen-2-yl]piperazin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; sodium triacetoxyborohydride / methanol; H₂O

2: 65 percent / sodium iodide; ethyldiisopropylamine / acetonitrile; dimethylformamide / 0.5 h / 130 °C / microwave irradiation

3: hydrogen; ammonia / Raney nickel / dimethylformamide; H₂O / 16 h / 20 °C

With ammonia; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; sodium iodide; nickel; In methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2006.12.028