Morpholine-4-carboxylic acid (2-chloro-1,2-diphenyl-ethyl)-amide

Base Information

• Chemical Name: Morpholine-4-carboxylic acid (2-chloro-1,2-diphenyl-ethyl)-amide
• CAS No.: 77444-17-8
• Molecular Formula: C₁₉H₂₁ClN₂O₂
• Molecular Weight: 344.841
• Mol file: 77444-17-8.mol

Synonyms:Morpholine-4-carboxylic acid (2-chloro-1,2-diphenyl-ethyl)-amide

Chemical Property of Morpholine-4-carboxylic acid (2-chloro-1,2-diphenyl-ethyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Morpholine-4-carboxylic acid (2-chloro-1,2-diphenyl-ethyl)-amide

There total 6 articles about Morpholine-4-carboxylic acid (2-chloro-1,2-diphenyl-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

morpholine (110-91-8,99108-56-2) + 2-Chloro-1,2-diphenylethyl isocyanate (343222-48-0) → Morpholine-4-carboxylic acid (2-chloro-1,2-diphenyl-ethyl)-amide (77444-17-8)

Guidance literature:

In diethyl ether; for 48h;

Reference yield:

(E)-1,2-diphenyl-ethene (103-30-0) → Morpholine-4-carboxylic acid (2-chloro-1,2-diphenyl-ethyl)-amide (77444-17-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / benzene / 0.67 h / Heating

2: 78 percent / Phosphorus pentachloride / 3 h / 95 - 100 °C

3: 88 percent / diethyl ether / 48 h

With phosphorus pentachloride; In diethyl ether; benzene;

Reference yield:

Methyl N-chloro-N-(2-chloro-1,2-diphenylethyl)carbamate (77444-01-0) → Morpholine-4-carboxylic acid (2-chloro-1,2-diphenyl-ethyl)-amide (77444-17-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / Phosphorus pentachloride / 3 h / 95 - 100 °C

2: 88 percent / diethyl ether / 48 h

With phosphorus pentachloride; In diethyl ether;

upstream raw materials:

morpholine

2-Chloro-1,2-diphenylethyl isocyanate

(E)-1,2-diphenyl-ethene

Ethyl N-(2-chloro-1,2-diphenylethyl)carbamate

Downstream raw materials:

Z-N,N-Dimethyl-2,3-diphenyl-1-aziridinecarboxamide

Z-Piperidide of 2,3-diphenyl-1-aziridinecarboxylic acid

cis-2,3-diphenylaziridine