4-[1-(2-chloro-benzyl)-5-fluoro-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-ylamino]-N-hydroxy-benzamide.

Base Information

Chemical Name:4-[1-(2-chloro-benzyl)-5-fluoro-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-ylamino]-N-hydroxy-benzamide.
CAS No.:1390618-54-8
Molecular Formula:C₂₃H₁₉ClFN₃O₃
Molecular Weight:439.874
Hs Code.:

Synonyms:4-[1-(2-chloro-benzyl)-5-fluoro-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-ylamino]-N-hydroxy-benzamide.

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Chemical Property of 4-[1-(2-chloro-benzyl)-5-fluoro-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-ylamino]-N-hydroxy-benzamide.

Chemical Property:

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Technology Process of 4-[1-(2-chloro-benzyl)-5-fluoro-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-ylamino]-N-hydroxy-benzamide.

There total 9 articles about 4-[1-(2-chloro-benzyl)-5-fluoro-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-ylamino]-N-hydroxy-benzamide. which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1390618-92-4
4-[1-(4-chloro-phenyl)-5-fluoro-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-ylamino]-benzoic acid methyl ester

: 1390618-54-8
4-[1-(2-chloro-benzyl)-5-fluoro-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-ylamino]-N-hydroxy-benzamide.

Guidance literature:: With hydroxylamine; potassium hydroxide; In methanol; water; at 20 ℃; for 3h;

Reference yield:

: 1390618-93-5
4-[1-(2-chloro-benzyl)-5-fluoro-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-ylamino]-benzoic acid methyl ester

: 1390618-54-8
4-[1-(2-chloro-benzyl)-5-fluoro-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-ylamino]-N-hydroxy-benzamide.

Guidance literature:: With hydroxylamine; potassium hydroxide; In methanol; at 20 ℃; for 3h;

Reference yield:

: 56341-41-4
5-fluoroindol-2(3H)-one

: 1390618-54-8
4-[1-(2-chloro-benzyl)-5-fluoro-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-ylamino]-N-hydroxy-benzamide.

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / 4 h / 20 °C

2: methanol; sodium tetrahydroborate / 3 h / 0 - 20 °C

3: pyridinium hydrobromide perbromide / water; tert-butyl alcohol / 2 h / 20 °C

4: triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C

5: potassium carbonate / copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane / N,N-dimethyl-formamide / 90 °C

6: hydroxylamine; potassium hydroxide / methanol; water / 3 h / 20 °C

With methanol; sodium tetrahydroborate; pyridinium hydrobromide perbromide; hydroxylamine; potassium carbonate; triethylamine; potassium hydroxide; copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;