Technology Process of C25H21BrN4O3S
There total 8 articles about C25H21BrN4O3S which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine / tetrahydrofuran / 16 h / 20 °C
2.1: water; sodium hydroxide / 0.5 h / 90 °C / Inert atmosphere
2.2: 18 h / 70 °C
3.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl acetamide / 48 h / 25 °C
3.2: 1 h / Reflux
With
water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
In
tetrahydrofuran; N,N-dimethyl acetamide;
DOI:10.1016/j.bmcl.2014.07.001
- Guidance literature:
-
C14H10N2O3S; 1-[(4-bromophenyl)carbonyl]piperazine;
With
O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl acetamide;
at 25 ℃;
for 48h;
With
water;
for 1h;
Reflux;
DOI:10.1016/j.bmcl.2014.07.001
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: trifluoroacetic acid / dichloromethane / 25 °C
2.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl acetamide / 48 h / 25 °C
2.2: 1 h / Reflux
With
O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
dichloromethane; N,N-dimethyl acetamide;
DOI:10.1016/j.bmcl.2014.07.001
