1-[4-(3-{4-[Amino-bis-(4-fluoro-phenyl)-methyl]-piperidin-1-yl}-propoxy)-3-methoxy-phenyl]-ethanone

Base Information

Chemical Name:1-[4-(3-{4-[Amino-bis-(4-fluoro-phenyl)-methyl]-piperidin-1-yl}-propoxy)-3-methoxy-phenyl]-ethanone
CAS No.:135257-02-2
Molecular Formula:C₃₀H₃₄F₂N₂O₃
Molecular Weight:508.608
Hs Code.:

Synonyms:1-[4-(3-{4-[Amino-bis-(4-fluoro-phenyl)-methyl]-piperidin-1-yl}-propoxy)-3-methoxy-phenyl]-ethanone

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Chemical Property of 1-[4-(3-{4-[Amino-bis-(4-fluoro-phenyl)-methyl]-piperidin-1-yl}-propoxy)-3-methoxy-phenyl]-ethanone

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Technology Process of 1-[4-(3-{4-[Amino-bis-(4-fluoro-phenyl)-methyl]-piperidin-1-yl}-propoxy)-3-methoxy-phenyl]-ethanone

There total 4 articles about 1-[4-(3-{4-[Amino-bis-(4-fluoro-phenyl)-methyl]-piperidin-1-yl}-propoxy)-3-methoxy-phenyl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 135256-88-1
4-<2-amino-1,1-bis(4-fluorophenyl)-2-oxoethyl>-1-piperidinecarboxylic acid methyl ester

: 135257-02-2
1-[4-(3-{4-[Amino-bis-(4-fluoro-phenyl)-methyl]-piperidin-1-yl}-propoxy)-3-methoxy-phenyl]-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: 50percent aq. NaOH, Br₂ / 16 h / Ambient temperature

2: 50percent aq. NaOH / methanol / 16 h / Heating

3: K₂CO₃, KI / butan-1-ol / Heating

With sodium hydroxide; bromine; potassium carbonate; potassium iodide; In methanol; butan-1-ol;
DOI:10.1021/jm00114a009

Reference yield:

: 135256-89-2
4-methyl>-1-piperidinecarboxylic acid methyl ester

: 135257-02-2
1-[4-(3-{4-[Amino-bis-(4-fluoro-phenyl)-methyl]-piperidin-1-yl}-propoxy)-3-methoxy-phenyl]-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 50percent aq. NaOH / methanol / 16 h / Heating

2: K₂CO₃, KI / butan-1-ol / Heating

With sodium hydroxide; potassium carbonate; potassium iodide; In methanol; butan-1-ol;
DOI:10.1021/jm00114a009

Reference yield:

: 135256-87-0
α,α-bis(4-fluorophenyl)-4-piperidineacetamide hydrochloride

: 135257-02-2
1-[4-(3-{4-[Amino-bis-(4-fluoro-phenyl)-methyl]-piperidin-1-yl}-propoxy)-3-methoxy-phenyl]-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: NaHCO₃ / CH₂Cl₂ / Ambient temperature

2: 50percent aq. NaOH, Br₂ / 16 h / Ambient temperature

3: 50percent aq. NaOH / methanol / 16 h / Heating

4: K₂CO₃, KI / butan-1-ol / Heating

With sodium hydroxide; bromine; sodium hydrogencarbonate; potassium carbonate; potassium iodide; In methanol; dichloromethane; butan-1-ol;
DOI:10.1021/jm00114a009