5-amino-3-(4-trifluoromethylphenyl)isoquinolin-1(2H)-one hydrobromide

Base Information

Chemical Name:5-amino-3-(4-trifluoromethylphenyl)isoquinolin-1(2H)-one hydrobromide
CAS No.:1450606-05-9
Molecular Formula:BrH*C₁₆H₁₁F₃N₂O
Molecular Weight:385.183
Hs Code.:

Synonyms:5-amino-3-(4-trifluoromethylphenyl)isoquinolin-1(2H)-one hydrobromide

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Chemical Property of 5-amino-3-(4-trifluoromethylphenyl)isoquinolin-1(2H)-one hydrobromide

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Technology Process of 5-amino-3-(4-trifluoromethylphenyl)isoquinolin-1(2H)-one hydrobromide

There total 6 articles about 5-amino-3-(4-trifluoromethylphenyl)isoquinolin-1(2H)-one hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1613435-24-7
5-amino-1-methoxy-3-(4-trifluoromethylphenyl)isoquinoline

: 1450606-05-9
5-amino-3-(4-trifluoromethylphenyl)isoquinolin-1(2H)-one hydrobromide

Guidance literature:: With hydrogen bromide; acetic acid; at 65 ℃; for 7h;

Reference yield:

: 1613435-38-3
3-bromo-1-methoxy-5-nitro-isoquinoline

: 1450606-05-9
5-amino-3-(4-trifluoromethylphenyl)isoquinolin-1(2H)-one hydrobromide

Guidance literature:: Multi-step reaction with 3 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate / N,N-dimethyl-formamide / 16 h / 135 °C

2: palladium 10% on activated carbon; hydrogen / ethanol / 5.5 h / 20 °C

3: hydrogen bromide; acetic acid / 7 h / 65 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen bromide; hydrogen; acetic acid; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1613435-44-1
1-methoxy-5-nitro-3-(4-trifluoromethylphenyl)isoquinoline

: 1450606-05-9
5-amino-3-(4-trifluoromethylphenyl)isoquinolin-1(2H)-one hydrobromide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 5.5 h / 20 °C

2: hydrogen bromide; acetic acid / 7 h / 65 °C

With palladium 10% on activated carbon; hydrogen bromide; hydrogen; acetic acid; In ethanol;