(3aR,4R,6R,6aR)-4-(2-Chloro-ethoxy)-2-(4-methoxy-phenyl)-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxole

Base Information

Chemical Name:(3aR,4R,6R,6aR)-4-(2-Chloro-ethoxy)-2-(4-methoxy-phenyl)-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxole
CAS No.:127877-14-9
Molecular Formula:C₃₄H₃₃ClO₆
Molecular Weight:573.085
Hs Code.:

Synonyms:(3aR,4R,6R,6aR)-4-(2-Chloro-ethoxy)-2-(4-methoxy-phenyl)-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxole

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Chemical Property of (3aR,4R,6R,6aR)-4-(2-Chloro-ethoxy)-2-(4-methoxy-phenyl)-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxole

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Technology Process of (3aR,4R,6R,6aR)-4-(2-Chloro-ethoxy)-2-(4-methoxy-phenyl)-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxole

There total 4 articles about (3aR,4R,6R,6aR)-4-(2-Chloro-ethoxy)-2-(4-methoxy-phenyl)-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: 127877-13-8
(2R,3R,4S,5R)-2-(2-Chloro-ethoxy)-5-trityloxymethyl-tetrahydro-furan-3,4-diol

: 127877-14-9
(3aR,4R,6R,6aR)-4-(2-Chloro-ethoxy)-2-(4-methoxy-phenyl)-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxole

Guidance literature:: With pyridinium p-toluenesulfonate; In N,N-dimethyl-formamide; for 4h; Ambient temperature;
DOI:10.1016/S0040-4039(00)94611-2

Reference yield:

: 6974-32-9
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

: 127877-14-9
(3aR,4R,6R,6aR)-4-(2-Chloro-ethoxy)-2-(4-methoxy-phenyl)-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxole

Guidance literature:: Multi-step reaction with 4 steps

1: chlorosulfonic acid (CSA) / 12 h / Ambient temperature

2: 1percent KOH / methanol / 1 h / Ambient temperature

3: pyridine / 1.5 h / 80 °C

4: 96 percent / PPTS / dimethylformamide / 4 h / Ambient temperature

With pyridine; chlorosulfonic acid; potassium hydroxide; pyridinium p-toluenesulfonate; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)94611-2

Reference yield:

: 64526-71-2,64949-99-1,64950-04-5
2-Chloroethyl β-D-ribofuranoside

: 127877-14-9
(3aR,4R,6R,6aR)-4-(2-Chloro-ethoxy)-2-(4-methoxy-phenyl)-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxole

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 1.5 h / 80 °C

2: 96 percent / PPTS / dimethylformamide / 4 h / Ambient temperature

With pyridine; pyridinium p-toluenesulfonate; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)94611-2