(Z,2S,3S)-6-(benzyloxy)-2-(tert-butyl-dimethyl-silanyloxy)-hex-4-en-3-ol

Base Information

Chemical Name:(Z,2S,3S)-6-(benzyloxy)-2-(tert-butyl-dimethyl-silanyloxy)-hex-4-en-3-ol
CAS No.:908300-12-9
Molecular Formula:C₁₉H₃₂O₃Si
Molecular Weight:336.547
Hs Code.:

Synonyms:(Z,2S,3S)-6-(benzyloxy)-2-(tert-butyl-dimethyl-silanyloxy)-hex-4-en-3-ol

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Chemical Property of (Z,2S,3S)-6-(benzyloxy)-2-(tert-butyl-dimethyl-silanyloxy)-hex-4-en-3-ol

Chemical Property:

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Technology Process of (Z,2S,3S)-6-(benzyloxy)-2-(tert-butyl-dimethyl-silanyloxy)-hex-4-en-3-ol

There total 3 articles about (Z,2S,3S)-6-(benzyloxy)-2-(tert-butyl-dimethyl-silanyloxy)-hex-4-en-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 87727-28-4
(S)-2-tert-butyl-dimethyl-silanyloxy propanal

: 478166-34-6
((Z)-3-Benzyloxy-propenyl)-dicyclohexyl-borane

: (Z,2S,3R)-6-(benzyloxy)-2-(tert-butyl-dimethyl-silanyloxy)-hex-4-en-3-ol

: 908300-12-9
(Z,2S,3S)-6-(benzyloxy)-2-(tert-butyl-dimethyl-silanyloxy)-hex-4-en-3-ol

Guidance literature:: ((Z)-3-Benzyloxy-propenyl)-dicyclohexyl-borane; With diethylzinc; In toluene; at -78 ℃; for 0.333333h;

(S)-2-tert-butyl-dimethyl-silanyloxy propanal; In toluene; at 0 - 20 ℃; for 12h;
DOI:10.1021/ja061973n

Reference yield:

: ((Z)-3-Benzyloxy-1-bromo-propenyl)-dicyclohexyl-borane

: 908300-12-9
(Z,2S,3S)-6-(benzyloxy)-2-(tert-butyl-dimethyl-silanyloxy)-hex-4-en-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: t-BuLi / tetrahydrofuran; pentane / 1.25 h / -78 - 20 °C

2.1: diethylzinc / toluene / 0.33 h / -78 °C

2.2: toluene / 12 h / 0 - 20 °C

With tert.-butyl lithium; diethylzinc; In tetrahydrofuran; toluene; pentane;
DOI:10.1021/ja061973n

Reference yield:

: 218431-34-6
(((3-bromoprop-2-yn-1-yl)oxy)methyl)benzene

: 908300-12-9
(Z,2S,3S)-6-(benzyloxy)-2-(tert-butyl-dimethyl-silanyloxy)-hex-4-en-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 0.42 h / 0 - 20 °C

2.1: t-BuLi / tetrahydrofuran; pentane / 1.25 h / -78 - 20 °C

3.1: diethylzinc / toluene / 0.33 h / -78 °C

3.2: toluene / 12 h / 0 - 20 °C

With tert.-butyl lithium; diethylzinc; In tetrahydrofuran; toluene; pentane;
DOI:10.1021/ja061973n