6-(tert-butyl-diphenyl-silanyloxymethyl)-6-methyl-5,6-dihydro-4H-pyrimidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

Base Information

Chemical Name:6-(tert-butyl-diphenyl-silanyloxymethyl)-6-methyl-5,6-dihydro-4H-pyrimidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester
CAS No.:477200-19-4
Molecular Formula:C₃₀H₄₂N₂O₅Si
Molecular Weight:538.759
Hs Code.:

6-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-6-methyl-5,6-dihydro-4<i>H</i>-pyrimidine-1,4-dicarboxylic acid 1-<i>tert</i>-butyl ester 4-ethyl ester

Synonyms:6-(tert-butyl-diphenyl-silanyloxymethyl)-6-methyl-5,6-dihydro-4H-pyrimidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

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Chemical Property of 6-(tert-butyl-diphenyl-silanyloxymethyl)-6-methyl-5,6-dihydro-4H-pyrimidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

Chemical Property:

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Technology Process of 6-(tert-butyl-diphenyl-silanyloxymethyl)-6-methyl-5,6-dihydro-4H-pyrimidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

There total 9 articles about 6-(tert-butyl-diphenyl-silanyloxymethyl)-6-methyl-5,6-dihydro-4H-pyrimidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 477200-19-4
6-(tert-butyl-diphenyl-silanyloxymethyl)-6-methyl-5,6-dihydro-4H-pyrimidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine

2: NaN₃ / dimethylformamide / 25 °C

3: H₂ / Pd/C

4: POCl₃; 2,6-di-tert-butyl-4-methylpyridine

With pyridine; sodium azide; 2,6-di-tert-butyl-4-methylpyridine; hydrogen; trichlorophosphate; palladium on activated charcoal; In N,N-dimethyl-formamide;
DOI:10.1021/ja028139s

Reference yield:

: 208242-93-7
ethyl (2R)-4-(tert-butyldiphenylsilyloxymethyl)-2-hydroxy-4-pentenoate

: 477200-19-4
6-(tert-butyl-diphenyl-silanyloxymethyl)-6-methyl-5,6-dihydro-4H-pyrimidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: H₂; Rh(cod)2OTf; (R)-4,12-bis(diphenylphosphino)-[2,2]-paracyclophane / CH₂Cl₂ / 51716.2 Torr

2: ClSO₂NCO; HCO₂H

3: 80 percent / Rh₂(OAc)4; PhI(OAc)2; MgO / CH₂Cl₂

4: pyridine

5: NaN₃ / dimethylformamide / 25 °C

6: H₂ / Pd/C

7: POCl₃; 2,6-di-tert-butyl-4-methylpyridine

With pyridine; dirhodium tetraacetate; formic acid; sodium azide; isocyanate de chlorosulfonyle; 2,6-di-tert-butyl-4-methylpyridine; bis(cycloocta-1,5-diene)rhodium(I) trifluoromethanesulfonate; [bis(acetoxy)iodo]benzene; (R)-4,12-bis(diphenylphosphino)-[2,2]-paracyclophane; hydrogen; magnesium oxide; trichlorophosphate; palladium on activated charcoal; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja028139s

Reference yield:

: 5-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-4-methyl-pentanoic acid ethyl ester

: 477200-19-4
6-(tert-butyl-diphenyl-silanyloxymethyl)-6-methyl-5,6-dihydro-4H-pyrimidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: ClSO₂NCO; HCO₂H

2: 80 percent / Rh₂(OAc)4; PhI(OAc)2; MgO / CH₂Cl₂

3: pyridine

4: NaN₃ / dimethylformamide / 25 °C

5: H₂ / Pd/C

6: POCl₃; 2,6-di-tert-butyl-4-methylpyridine

With pyridine; dirhodium tetraacetate; formic acid; sodium azide; isocyanate de chlorosulfonyle; 2,6-di-tert-butyl-4-methylpyridine; [bis(acetoxy)iodo]benzene; hydrogen; magnesium oxide; trichlorophosphate; palladium on activated charcoal; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja028139s