[(S)-1-[(S)-1-Hydroxymethyl-3-(trityl-carbamoyl)-propylcarbamoyl]-2-(4-iodo-phenyl)-ethyl]-carbamic acid tert-butyl ester

Base Information

• Chemical Name: [(S)-1-[(S)-1-Hydroxymethyl-3-(trityl-carbamoyl)-propylcarbamoyl]-2-(4-iodo-phenyl)-ethyl]-carbamic acid tert-butyl ester
• CAS No.: 211186-08-2
• Molecular Formula: C₃₈H₄₂IN₃O₅
• Molecular Weight: 747.673

Synonyms:[(S)-1-[(S)-1-Hydroxymethyl-3-(trityl-carbamoyl)-propylcarbamoyl]-2-(4-iodo-phenyl)-ethyl]-carbamic acid tert-butyl ester

Chemical Property of [(S)-1-[(S)-1-Hydroxymethyl-3-(trityl-carbamoyl)-propylcarbamoyl]-2-(4-iodo-phenyl)-ethyl]-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(S)-1-[(S)-1-Hydroxymethyl-3-(trityl-carbamoyl)-propylcarbamoyl]-2-(4-iodo-phenyl)-ethyl]-carbamic acid tert-butyl ester

There total 2 articles about [(S)-1-[(S)-1-Hydroxymethyl-3-(trityl-carbamoyl)-propylcarbamoyl]-2-(4-iodo-phenyl)-ethyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Boc-4-I-Phe-OH (103882-09-3,62129-44-6) → [(S)-1-[(S)-1-Hydroxymethyl-3-(trityl-carbamoyl)-propylcarbamoyl]-2-(4-iodo-phenyl)-ethyl]-carbamic acid tert-butyl ester (211186-08-2)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 1 h / 23 °C

2: tetrahydrofuran / 23 °C

In tetrahydrofuran;

DOI:10.1021/jm9800696

Reference yield:

[(S)-2-Imidazol-1-yl-1-(4-iodo-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester + (S)-4-Amino-5-hydroxy-pentanoic acid trityl-amide (199005-88-4) → [(S)-1-[(S)-1-Hydroxymethyl-3-(trityl-carbamoyl)-propylcarbamoyl]-2-(4-iodo-phenyl)-ethyl]-carbamic acid tert-butyl ester (211186-08-2)

Guidance literature:

In tetrahydrofuran; at 23 ℃; Yield given;

DOI:10.1021/jm9800696

Reference yield: 85.0%

potassium cyanide (151-50-8) + [(S)-1-[(S)-1-Hydroxymethyl-3-(trityl-carbamoyl)-propylcarbamoyl]-2-(4-iodo-phenyl)-ethyl]-carbamic acid tert-butyl ester (211186-08-2) → {(S)-2-(4-Cyano-phenyl)-1-[(S)-1-hydroxymethyl-3-(trityl-carbamoyl)-propylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester (211186-09-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; Heating;

DOI:10.1021/jm9800696

upstream raw materials:

(S)-4-Amino-5-hydroxy-pentanoic acid trityl-amide

N-Boc-4-I-Phe-OH

Downstream raw materials:

{(S)-2-(4-Cyano-phenyl)-1-[(S)-1-hydroxymethyl-3-(trityl-carbamoyl)-propylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

{(S)-2-(4-Carbamoyl-phenyl)-1-[(S)-1-hydroxymethyl-3-(trityl-carbamoyl)-propylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

((S)-1-{(S)-2-(4-Cyano-phenyl)-1-[(S)-1-formyl-3-(trityl-carbamoyl)-propylcarbamoyl]-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester

((S)-1-{(S)-2-(4-Cyano-phenyl)-1-[(S)-1-hydroxymethyl-3-(trityl-carbamoyl)-propylcarbamoyl]-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 211186-08-2 [(S)-1-[(S)-1-Hydroxymethyl-3-(trityl-carbamoyl)-propylcarbamoyl]-2-(4-iodo-phenyl)-ethyl]-carbamic acid tert-butyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send