C₅₃H₆₂N₁₀O₁₂Si

Base Information

• Chemical Name: C₅₃H₆₂N₁₀O₁₂Si
• CAS No.: 215248-73-0
• Molecular Formula: C₅₃H₆₂N₁₀O₁₂Si
• Molecular Weight: 1059.22
• Mol file: 215248-73-0.mol

Synonyms:C₅₃H₆₂N₁₀O₁₂Si

Chemical Property of C₅₃H₆₂N₁₀O₁₂Si

Chemical Property:

Purity/Quality:

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Technology Process of C₅₃H₆₂N₁₀O₁₂Si

There total 1 articles about C₅₃H₆₂N₁₀O₁₂Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

2-N-isobutyryl-3'-O-tert-butyldiphenylsilyl-2'-deoxyguanosine (114745-19-6) + Phenoxy-acetic acid (2R,3S,5R)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-3-methylsulfanylmethoxy-tetrahydro-furan-2-ylmethyl ester → C53H62N10O12Si (215248-73-0)

Guidance literature:

With N-iodo-succinimide; trifluorormethanesulfonic acid; In dichloromethane; acetonitrile; at -30 ℃; for 1h;

DOI:10.1021/jm970766i

Reference yield:

C53H62N10O12Si (215248-73-0) → C45H56N10O10Si

Guidance literature:

With ammonia; In methanol; for 0.5h; Ambient temperature;

DOI:10.1021/jm970766i

Reference yield:

C53H62N10O12Si (215248-73-0) → C59H73N12O13P

Guidance literature:

Multi-step reaction with 4 steps

1: NH₃ / methanol / 0.5 h / Ambient temperature

2: pyridine / Ambient temperature

3: 84 percent / (n-Bu)4NF / tetrahydrofuran / 0.5 h / Ambient temperature

4: 78 percent / N,N-diisopropylethylamine / CH₂Cl₂ / a) 0 deg C, 30 min, b) RT, 1 h

With pyridine; tetrabutyl ammonium fluoride; ammonia; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1021/jm970766i

upstream raw materials:

2-N-isobutyryl-3'-O-tert-butyldiphenylsilyl-2'-deoxyguanosine

Downstream raw materials:

C₅₀H₅₆N₁₀O₁₂