(S)-2-{(S)-2-tert-Butoxycarbonylamino-1-[((S)-1-carbamoyl-2-phenyl-ethylamino)-methyl]-hexylamino}-succinic acid dimethyl ester

Base Information

Chemical Name:(S)-2-{(S)-2-tert-Butoxycarbonylamino-1-[((S)-1-carbamoyl-2-phenyl-ethylamino)-methyl]-hexylamino}-succinic acid dimethyl ester
CAS No.:431059-55-1
Molecular Formula:C₂₇H₄₄N₄O₇
Molecular Weight:536.669
Hs Code.:

Synonyms:(S)-2-{(S)-2-tert-Butoxycarbonylamino-1-[((S)-1-carbamoyl-2-phenyl-ethylamino)-methyl]-hexylamino}-succinic acid dimethyl ester

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Chemical Property of (S)-2-{(S)-2-tert-Butoxycarbonylamino-1-[((S)-1-carbamoyl-2-phenyl-ethylamino)-methyl]-hexylamino}-succinic acid dimethyl ester

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Technology Process of (S)-2-{(S)-2-tert-Butoxycarbonylamino-1-[((S)-1-carbamoyl-2-phenyl-ethylamino)-methyl]-hexylamino}-succinic acid dimethyl ester

There total 1 articles about (S)-2-{(S)-2-tert-Butoxycarbonylamino-1-[((S)-1-carbamoyl-2-phenyl-ethylamino)-methyl]-hexylamino}-succinic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 5241-58-7
L-Phenylalanine amide

: (S)-2-((S)-2-tert-Butoxycarbonylamino-1-cyano-hexylamino)-succinic acid dimethyl ester

: [(S)-6-((S)-1-tert-Butoxycarbonylamino-pentyl)-3-oxo-piperazin-2-yl]-acetic acid methyl ester

: 431059-55-1
(S)-2-{(S)-2-tert-Butoxycarbonylamino-1-[((S)-1-carbamoyl-2-phenyl-ethylamino)-methyl]-hexylamino}-succinic acid dimethyl ester

Guidance literature:: With hydrogen; triethylamine; palladium on activated charcoal; In methanol; at 20 ℃; for 8h; under 760 Torr;
DOI:10.1016/S0040-4039(02)00012-6

Reference yield: 60.0%

: 431059-55-1
(S)-2-{(S)-2-tert-Butoxycarbonylamino-1-[((S)-1-carbamoyl-2-phenyl-ethylamino)-methyl]-hexylamino}-succinic acid dimethyl ester

: 438579-62-5
[(2S,6R)-6-((S)-1-tert-Butoxycarbonylamino-pentyl)-4-((S)-1-carbamoyl-2-phenyl-ethyl)-3-oxo-piperazin-2-yl]-acetic acid methyl ester

: 438579-63-6
[(2S,6S)-6-((S)-1-tert-Butoxycarbonylamino-pentyl)-4-((S)-1-carbamoyl-2-phenyl-ethyl)-3-oxo-piperazin-2-yl]-acetic acid methyl ester

Guidance literature:: In toluene; at 100 ℃; for 120h;
DOI:10.1021/jo0256336

Reference yield:

: 431059-55-1
(S)-2-{(S)-2-tert-Butoxycarbonylamino-1-[((S)-1-carbamoyl-2-phenyl-ethylamino)-methyl]-hexylamino}-succinic acid dimethyl ester

: 438579-76-1
[(2S,6R)-6-{(S)-1-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-pentyl}-4-((S)-1-carbamoyl-2-phenyl-ethyl)-3-oxo-piperazin-2-yl]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / toluene / 120 h / 100 °C

2: HCl / methanol / 5 h / 20 °C

3: benzotriazol-1-yloxytris(dimethylamino)phosphonium PF₆; TEA / CH₂Cl₂ / 16 h / 20 °C

With hydrogenchloride; TEA; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In methanol; dichloromethane; toluene;
DOI:10.1021/jo0256336