Technology Process of dimethyl 2-((2R,3R,6S)-1,6-dibenzyl-2-methyl-1,2,3,6-tetrahydropyridin-3-yl)malonate
There total 5 articles about dimethyl 2-((2R,3R,6S)-1,6-dibenzyl-2-methyl-1,2,3,6-tetrahydropyridin-3-yl)malonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S)-1-((2R,5S)-1,5-dibenzyl-2,5-dihydro-1H-pyrrol-2-yl)ethanol;
With
trifluoromethylsulfonic anhydride;
In
dichloromethane;
at -15 ℃;
Inert atmosphere;
sodiodimethylmalonate;
In
tetrahydrofuran; dichloromethane;
at -15 - 20 ℃;
regioselective reaction;
Inert atmosphere;
DOI:10.1021/ol201349k
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium carbonate / acetone / 16 h / 20 °C / Inert atmosphere
2.1: trifluoromethylsulfonic anhydride / dichloromethane / -15 °C / Inert atmosphere
2.2: -15 - 20 °C / Inert atmosphere
With
trifluoromethylsulfonic anhydride; potassium carbonate;
In
dichloromethane; acetone;
DOI:10.1021/ol201349k
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tetrabutyl ammonium fluoride / tetrahydrofuran; ethanol / 0.08 h / Inert atmosphere
1.2: 24 h / Inert atmosphere; Reflux
2.1: toluene-4-sulfonic acid / dichloromethane / 0.25 h / Inert atmosphere
2.2: 16 h / Inert atmosphere; Reflux
3.1: potassium carbonate / acetone / 16 h / 20 °C / Inert atmosphere
4.1: trifluoromethylsulfonic anhydride / dichloromethane / -15 °C / Inert atmosphere
4.2: -15 - 20 °C / Inert atmosphere
With
trifluoromethylsulfonic anhydride; tetrabutyl ammonium fluoride; potassium carbonate; toluene-4-sulfonic acid;
In
tetrahydrofuran; ethanol; dichloromethane; acetone;
DOI:10.1021/ol201349k
