{[4-((S)-2-Acetylamino-2-{1-[(S)-2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-ethyl)-phenyl]-difluoro-methyl}-phosphonic acid diethyl ester

Base Information

Chemical Name:{[4-((S)-2-Acetylamino-2-{1-[(S)-2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-ethyl)-phenyl]-difluoro-methyl}-phosphonic acid diethyl ester
CAS No.:220193-70-4
Molecular Formula:C₄₀H₅₂F₂N₅O₈P
Molecular Weight:799.852
Hs Code.:

{[4-((S)-2-Acetylamino-2-{1-[(S)-2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-ethyl)-phenyl]-difluoro-methyl}-phosphonic acid diethyl ester

Synonyms:{[4-((S)-2-Acetylamino-2-{1-[(S)-2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-ethyl)-phenyl]-difluoro-methyl}-phosphonic acid diethyl ester

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Chemical Property of {[4-((S)-2-Acetylamino-2-{1-[(S)-2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-ethyl)-phenyl]-difluoro-methyl}-phosphonic acid diethyl ester

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Technology Process of {[4-((S)-2-Acetylamino-2-{1-[(S)-2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-ethyl)-phenyl]-difluoro-methyl}-phosphonic acid diethyl ester

There total 3 articles about {[4-((S)-2-Acetylamino-2-{1-[(S)-2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-ethyl)-phenyl]-difluoro-methyl}-phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 220193-52-2
(2S)-2-amino-N₁-[3-(1-naphthalenyl)propyl]butanediamide

: 220193-70-4
{[4-((S)-2-Acetylamino-2-{1-[(S)-2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-ethyl)-phenyl]-difluoro-methyl}-phosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) DIPCDI, HOBT*H₂O / 1.) DMF, RT, 20 min, 2.) DMF, RT, overnight

2: TFA / CH₂Cl₂ / 1 h / Ambient temperature

3: Et₃N / dimethylformamide / 2 h / Ambient temperature

With 1,3-di-tert-butylcarbodiimide; benzotriazol-1-ol; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980388x

Reference yield:

: 220193-51-1
{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexyl}-carbamic acid tert-butyl ester

: 220193-70-4
{[4-((S)-2-Acetylamino-2-{1-[(S)-2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-ethyl)-phenyl]-difluoro-methyl}-phosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: TFA, triethylsilane / 1 h / Ambient temperature

2: 1.) DIPCDI, HOBT*H₂O / 1.) DMF, RT, 20 min, 2.) DMF, RT, overnight

3: TFA / CH₂Cl₂ / 1 h / Ambient temperature

4: Et₃N / dimethylformamide / 2 h / Ambient temperature

With triethylsilane; 1,3-di-tert-butylcarbodiimide; benzotriazol-1-ol; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980388x

Reference yield:

: 220193-66-8
{[4-((S)-2-tert-Butoxycarbonylamino-2-{1-[(S)-2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-ethyl)-phenyl]-difluoro-methyl}-phosphonic acid diethyl ester

: 220193-70-4
{[4-((S)-2-Acetylamino-2-{1-[(S)-2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-ethyl)-phenyl]-difluoro-methyl}-phosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: TFA / CH₂Cl₂ / 1 h / Ambient temperature

2: Et₃N / dimethylformamide / 2 h / Ambient temperature

With triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980388x