2-Amino-9-(beta-D-2,3-dideoxyribofuranosyl)purine

Base Information

• Chemical Name: 2-Amino-9-(beta-D-2,3-dideoxyribofuranosyl)purine
• CAS No.: 107550-74-3
• Molecular Formula: C10H13 N5 O2
• Molecular Weight: 235.246
• DSSTox Substance ID: DTXSID70148084
• Nikkaji Number: J324.624H
• Wikidata: Q83013530
• ChEMBL ID: CHEMBL439750
• Mol file: 107550-74-3.mol

Synonyms:2-Amino-ddP;107550-74-3;NSC 628953;2-Amino-9-(beta-D-2,3-dideoxyribofuranosyl)purine;NSC628953;CHEMBL439750;SCHEMBL9153085;DTXSID70148084;2-Amino-9-(.beta.-D-2,3-dideoxyribofuranosyl)purine;2-Amino-9-(2,3-dideoxy-beta-D-ribofuranosyl)-9H-purine;[(2S,5R)-5-(2-aminopurin-9-yl)tetrahydrofuran-2-yl]methanol

Chemical Property of 2-Amino-9-(beta-D-2,3-dideoxyribofuranosyl)purine

Chemical Property:

• Vapor Pressure: 7.23E-14mmHg at 25°C
• Boiling Point: 570.8°Cat760mmHg
• Flash Point: 299°C
• Density: 1.76g/cm³
• XLogP3: -1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 235.10692467
• Heavy Atom Count: 17
• Complexity: 279

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(OC1CO)N2C=NC3=CN=C(N=C32)N
• Isomeric SMILES: C1C[C@@H](O[C@@H]1CO)N2C=NC3=CN=C(N=C32)N

Technology Process of 2-Amino-9-(beta-D-2,3-dideoxyribofuranosyl)purine

There total 2 articles about 2-Amino-9-(beta-D-2,3-dideoxyribofuranosyl)purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

9H-purin-2-amine (452-06-2) + 2',3'-Dideoxyuridine (5983-09-5,153547-98-9) → iso-2',3'-dideoxyadenosine (107550-74-3)

Guidance literature:

at 50 ℃; for 2h; Escherichia coli JA-300 cells, pH 6.5;

DOI:10.1021/jm00109a012

Reference yield:

→ iso-2',3'-dideoxyadenosine (107550-74-3)

Guidance literature:

Reference yield:

iso-2',3'-dideoxyadenosine (107550-74-3) → 2,3-Didesoxy-β-D-glycero-pentofuranose (122999-44-4) + 9H-purin-2-amine (452-06-2)

Guidance literature:

With hydrogenchloride; at 22 ℃; rate of hydrolysis relative to dideoxyadenosine;

DOI:10.1021/jo00298a067

upstream raw materials:

9H-purin-2-amine

2',3'-Dideoxyuridine

Downstream raw materials:

2,3-Didesoxy-β-D-glycero-pentofuranose

9H-purin-2-amine