norcocaine

Base Information

• Chemical Name: norcocaine
• CAS No.: 134623-90-8
• Molecular Formula: C₁₆H₁₉NO₄
• Molecular Weight: 289.331

Synonyms:norcocaine

Chemical Property of norcocaine

Chemical Property:

Purity/Quality:

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Technology Process of norcocaine

There total 10 articles about norcocaine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 3-benzoyloxy-nortropane-2-carboxylic acid methyl ester (17366-45-9,18717-72-1,115460-07-6,134623-90-8)

Guidance literature:

Cocain, 1.) CCl3-CH2-O-COCl, 2.) Zn, Eg.;

DOI:10.1002/jps.2600671204

Reference yield:

→ Norkokain (17366-45-9,18717-72-1,115460-07-6,134623-90-8)

Guidance literature:

Vorstufe III, Ameisensaeure, Zn;

DOI:10.1002/jps.2600660133

Reference yield:

(1S,2S,3R,5R)-3-benzyloxy-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 8-tert-butyl ester 2-methyl ester (774586-32-2) → norcocaine (134623-90-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/ol048777a

upstream raw materials:

(1S,2S,3R,5R)-3-benzyloxy-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 8-tert-butyl ester 2-methyl ester

(2RS,5SR)-2,5-bis(oxoethyl)pyrrolidine-1-carboxylic acid tert-butyl ester

(1S,3R,5R)-2-formyl-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester

(2RS,5SR)-2,5-bis(2-hydroxyethyl)pyrrolidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

(+)-cocaine

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