Technology Process of 2-benzyloxy-6-(N,N-diethylcarbamyl)benzenesulfonyl chloride
There total 3 articles about 2-benzyloxy-6-(N,N-diethylcarbamyl)benzenesulfonyl chloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-benzyloxy-N,N-diethylbenzamide;
With
N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium;
In
diethyl ether; hexane;
at -78 ℃;
for 1h;
With
sulfur dioxide;
In
diethyl ether; hexane;
at -78 - 20 ℃;
for 1.25h;
With
N-chloro-succinimide; sodium phosphate;
In
water; ethyl acetate;
for 1h;
pH=6.0;
ice-cooling;
DOI:10.1016/S0040-4020(98)01029-1
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: SOCl2 / benzene / 1 h / Heating
2.1: 22.58 g / benzene / 0.75 h / Heating
3.1: TMEDA; tert-BuLi / diethyl ether; hexane / 1 h / -78 °C
3.2: sulfur dioxide / diethyl ether; hexane / 1.25 h / -78 - 20 °C
3.3: 47 percent / sodium phosphate; N-chlorosuccinimide / H2O; ethyl acetate / 1 h / pH 6.0 / ice-cooling
With
thionyl chloride; N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium;
In
diethyl ether; hexane; benzene;
1.1: Substitution / 2.1: Acylation / 3.1: Metallation / 3.2: sulfinylation / 3.3: Chlorination;
DOI:10.1016/S0040-4020(98)01029-1
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 22.58 g / benzene / 0.75 h / Heating
2.1: TMEDA; tert-BuLi / diethyl ether; hexane / 1 h / -78 °C
2.2: sulfur dioxide / diethyl ether; hexane / 1.25 h / -78 - 20 °C
2.3: 47 percent / sodium phosphate; N-chlorosuccinimide / H2O; ethyl acetate / 1 h / pH 6.0 / ice-cooling
With
N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium;
In
diethyl ether; hexane; benzene;
1.1: Acylation / 2.1: Metallation / 2.2: sulfinylation / 2.3: Chlorination;
DOI:10.1016/S0040-4020(98)01029-1
