N-(2-ethyl-4,5,6,7-tetrahydro-2H-indazol-3-yl)-4-(3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)thiazol-2-amine

Base Information

Chemical Name:N-(2-ethyl-4,5,6,7-tetrahydro-2H-indazol-3-yl)-4-(3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)thiazol-2-amine
CAS No.:1353570-40-7
Molecular Formula:C₂₂H₂₃FN₆S
Molecular Weight:422.529
Hs Code.:

Synonyms:N-(2-ethyl-4,5,6,7-tetrahydro-2H-indazol-3-yl)-4-(3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)thiazol-2-amine

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Chemical Property of N-(2-ethyl-4,5,6,7-tetrahydro-2H-indazol-3-yl)-4-(3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)thiazol-2-amine

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Technology Process of N-(2-ethyl-4,5,6,7-tetrahydro-2H-indazol-3-yl)-4-(3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)thiazol-2-amine

There total 7 articles about N-(2-ethyl-4,5,6,7-tetrahydro-2H-indazol-3-yl)-4-(3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1353569-78-4
1-(2-ethyl-4,5,6,7-tetrahydro-2H-indazol-3-yl)thiourea

: 2-bromo-1-(3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)ethanone hydrobromide

: 1353570-40-7
N-(2-ethyl-4,5,6,7-tetrahydro-2H-indazol-3-yl)-4-(3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)thiazol-2-amine

Guidance literature:: In ethanol; at 25 - 75 ℃; for 18.25h; Inert atmosphere;
DOI:10.1016/j.bmcl.2016.07.011

Reference yield:

: 1056050-42-0
1-(3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)ethanone

: 1353570-40-7
N-(2-ethyl-4,5,6,7-tetrahydro-2H-indazol-3-yl)-4-(3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)thiazol-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen bromide; bromine / acetic acid; chloroform; ethyl acetate / 1.5 h / 25 °C / pH 2 - 3 / Inert atmosphere

2: ethanol / 18.25 h / 25 - 75 °C / Inert atmosphere

With hydrogen bromide; bromine; In ethanol; chloroform; acetic acid; ethyl acetate;
DOI:10.1016/j.bmcl.2016.07.011

Reference yield:

: 1353569-76-2
N-((2-ethyl-4,5,6,7-tetrahydro-2H-indazol-3-yl)carbamothioyl)benzamide

: 1353570-40-7
N-(2-ethyl-4,5,6,7-tetrahydro-2H-indazol-3-yl)-4-(3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)thiazol-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / methanol / 18 h / 25 °C / Inert atmosphere

2: ethanol / 18.25 h / 25 - 75 °C / Inert atmosphere

With potassium carbonate; In methanol; ethanol;
DOI:10.1016/j.bmcl.2016.07.011