Technology Process of (2R,3S)-3-Benzyloxymethoxy-5-(4-methoxy-benzyloxy)-2-methyl-pentanal
There total 3 articles about (2R,3S)-3-Benzyloxymethoxy-5-(4-methoxy-benzyloxy)-2-methyl-pentanal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-Bu2BOTf; TEA / CH2Cl2 / 0.5 h / -40 - 0 °C
1.2: CH2Cl2 / 5 h / -78 - 0 °C
2.1: Me3Al / tetrahydrofuran / 3 h / -20 - 20 °C
3.1: DIPEA; TBAI / CH2Cl2 / 15 h / 20 °C
4.1: DIBAL / tetrahydrofuran / 1 h / -78 °C
With
di-n-butylboryl trifluoromethanesulfonate; TEA; trimethylaluminum; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ja016272z
- Guidance literature:
-
Multi-step reaction with 2 steps
1: DIPEA; TBAI / CH2Cl2 / 15 h / 20 °C
2: DIBAL / tetrahydrofuran / 1 h / -78 °C
With
tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ja016272z
- Guidance literature:
-
Multi-step reaction with 3 steps
1: Me3Al / tetrahydrofuran / 3 h / -20 - 20 °C
2: DIPEA; TBAI / CH2Cl2 / 15 h / 20 °C
3: DIBAL / tetrahydrofuran / 1 h / -78 °C
With
trimethylaluminum; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ja016272z
