2-((3-(1-carbamoyl-7-((2-(trimethylsilyl)ethoxy)carbonylamino)-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylamino)methyl)-5-chlorobenzoic acid

Base Information

Chemical Name:2-((3-(1-carbamoyl-7-((2-(trimethylsilyl)ethoxy)carbonylamino)-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylamino)methyl)-5-chlorobenzoic acid
CAS No.:1352835-72-3
Molecular Formula:C₃₃H₃₄ClN₅O₅Si
Molecular Weight:644.202
Hs Code.:

Synonyms:2-((3-(1-carbamoyl-7-((2-(trimethylsilyl)ethoxy)carbonylamino)-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylamino)methyl)-5-chlorobenzoic acid

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Chemical Property of 2-((3-(1-carbamoyl-7-((2-(trimethylsilyl)ethoxy)carbonylamino)-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylamino)methyl)-5-chlorobenzoic acid

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Technology Process of 2-((3-(1-carbamoyl-7-((2-(trimethylsilyl)ethoxy)carbonylamino)-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylamino)methyl)-5-chlorobenzoic acid

There total 13 articles about 2-((3-(1-carbamoyl-7-((2-(trimethylsilyl)ethoxy)carbonylamino)-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylamino)methyl)-5-chlorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5318-27-4
6-amino-1H-indole

: 1352835-72-3
2-((3-(1-carbamoyl-7-((2-(trimethylsilyl)ethoxy)carbonylamino)-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylamino)methyl)-5-chlorobenzoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / Inert atmosphere

2.1: 6.5 h / 115 °C

3.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 5.25 h / Inert atmosphere

4.1: hydrogenchloride / toluene; 1,4-dioxane / 16 h / 20 °C / Inert atmosphere

4.2: 6.5 h / 115 °C

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1 h

5.2: pH ~ 5

6.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 4-methyl-morpholine; ammonium chloride / N,N-dimethyl-formamide / 2.5 h

7.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 1 h

8.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane; tetrahydrofuran / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; lithium hydroxide monohydrate; water; hydrogen; sodium tris(acetoxy)borohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1352835-71-2
2-(trimethylsilyl)ethyl 4-(3-amino-2-methylphenyl)-1-carbamoyl-9H-pyrido[3,4-b]indol-7-ylcarbamate

: 4506-45-0
5-chloro-ortho-formylbenzoic acid

: 1352835-72-3
2-((3-(1-carbamoyl-7-((2-(trimethylsilyl)ethoxy)carbonylamino)-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylamino)methyl)-5-chlorobenzoic acid

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; dichloromethane; Inert atmosphere;

Reference yield:

: 78269-85-9
carbonic acid 2,5-dioxo-pyrrolidin-1-yl ester 2-(trimethylsilanyl)-ethyl ester

: 1352835-72-3
2-((3-(1-carbamoyl-7-((2-(trimethylsilyl)ethoxy)carbonylamino)-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylamino)methyl)-5-chlorobenzoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / Inert atmosphere

2.1: 6.5 h / 115 °C

3.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 5.25 h / Inert atmosphere

4.1: hydrogenchloride / toluene; 1,4-dioxane / 16 h / 20 °C / Inert atmosphere

4.2: 6.5 h / 115 °C

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1 h

5.2: pH ~ 5

6.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 4-methyl-morpholine; ammonium chloride / N,N-dimethyl-formamide / 2.5 h

7.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 1 h

8.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane; tetrahydrofuran / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; lithium hydroxide monohydrate; water; hydrogen; sodium tris(acetoxy)borohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;