(3S)-1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-N-cyclohexyl-3-piperidinecarboxamide

Base Information

Chemical Name:(3S)-1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-N-cyclohexyl-3-piperidinecarboxamide
CAS No.:1227919-91-6
Molecular Formula:C₂₃H₃₀N₈O
Molecular Weight:434.544
Hs Code.:

Synonyms:(3S)-1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-N-cyclohexyl-3-piperidinecarboxamide

Suppliers and Price of (3S)-1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-N-cyclohexyl-3-piperidinecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S)-1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-N-cyclohexyl-3-piperidinecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S)-1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-N-cyclohexyl-3-piperidinecarboxamide

There total 6 articles about (3S)-1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-N-cyclohexyl-3-piperidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 404827-77-6
ethyl 3-(3-(cyclopropanecarboxamido)-1H-indazol-6-yl)benzoate

: 1227919-91-6
(3S)-1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-N-cyclohexyl-3-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap / 5 h / 120 °C

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 2 h / 100 °C

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydrogencarbonate / 1,4-dioxane; water / 100 °C

3.2: 60 °C

With dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium hydrogencarbonate; In 1,4-dioxane; water; 3.1: Suzuki coupling;
DOI:10.1021/jm101527u

Reference yield:

: 1227916-64-4
C₁₉H₂₄BN₃O₅

: 1227912-26-6
C₁₆H₂₄ClN₅O

: 1227919-91-6
(3S)-1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-N-cyclohexyl-3-piperidinecarboxamide

Guidance literature:: C₁₉H₂₄BN₃O₅; C₁₆H₂₄ClN₅O; With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydrogencarbonate; In 1,4-dioxane; water; at 100 ℃;

With hydrogenchloride; In methanol; at 60 ℃;
DOI:10.1021/jm101527u

Reference yield:

: 872508-20-8
(3S)-N-cyclohexylpiperidine-3-carboxamide trifluoroacetate

: 1227919-91-6
(3S)-1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-N-cyclohexyl-3-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol; ethanol / 50 - 100 °C

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydrogencarbonate / 1,4-dioxane; water / 100 °C

2.2: 60 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydrogencarbonate; In 1,4-dioxane; methanol; ethanol; water; 2.1: Suzuki coupling;
DOI:10.1021/jm101527u