10-Acetyl-4-[5-benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-1,4,5,10-tetrahydrodipyrrin

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Chemical Name:10-Acetyl-4-[5-benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-1,4,5,10-tetrahydrodipyrrin
CAS No.:208238-39-5
Molecular Formula:C₄₅H₅₅N₃O₁₅
Molecular Weight:877.943
Hs Code.:

10-Acetyl-4-[5-benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-1,4,5,10-tetrahydrodipyrrin

Synonyms:10-Acetyl-4-[5-benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-1,4,5,10-tetrahydrodipyrrin

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Chemical Property of 10-Acetyl-4-[5-benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-1,4,5,10-tetrahydrodipyrrin

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Technology Process of 10-Acetyl-4-[5-benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-1,4,5,10-tetrahydrodipyrrin

There total 8 articles about 10-Acetyl-4-[5-benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-1,4,5,10-tetrahydrodipyrrin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 108-24-7
acetic anhydride

: 208238-33-9
4-[5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-1,4,5,10-tetrahydrodipyrrin

: 208238-39-5
10-Acetyl-4-[5-benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-1,4,5,10-tetrahydrodipyrrin

Guidance literature:: With dmap; In dichloromethane; for 15h; Ambient temperature;

Reference yield:

: 155435-03-3
4-[5-benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-9-(2,2,2-tribromoethoxycarbonyl)-4,5-dihydrodipyrrin-1(10H)-one

: 208238-39-5
10-Acetyl-4-[5-benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-1,4,5,10-tetrahydrodipyrrin

Guidance literature:: Multi-step reaction with 8 steps

1: Zn, glacial acetic acid / 0.5 h / Ambient temperature

2: DCC, DMAP / CH₂Cl₂ / 3 h / Ambient temperature

3: 71 percent / p-tolyl Davy's reagent / 1,2-dimethoxy-ethane / 0.17 h / Heating

4: 78 percent / AcOH, nickel boride, H₂ / methanol / 2 h

5: 80 percent / NaBH₄ / methanol / 0.08 h / Ambient temperature

6: TBAF / tetrahydrofuran / 3 h / Ambient temperature

7: 3 h / Ambient temperature

8: 92 percent / DMAP / CH₂Cl₂ / 15 h / Ambient temperature

With dmap; sodium tetrahydroborate; nickel boride; tetrabutyl ammonium fluoride; hydrogen; acetic acid; dicyclohexyl-carbodiimide; 2,4-bis(4-methylphenylthio)-1,3,2λ⁵,4λ⁵-dithiadiphosphetane-2,4-dithione; zinc; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane;

Reference yield:

: 155435-04-4
C₄₄H₅₁N₃O₁₇

: 208238-39-5
10-Acetyl-4-[5-benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-1,4,5,10-tetrahydrodipyrrin

Guidance literature:: Multi-step reaction with 7 steps

1: DCC, DMAP / CH₂Cl₂ / 3 h / Ambient temperature

2: 71 percent / p-tolyl Davy's reagent / 1,2-dimethoxy-ethane / 0.17 h / Heating

3: 78 percent / AcOH, nickel boride, H₂ / methanol / 2 h

4: 80 percent / NaBH₄ / methanol / 0.08 h / Ambient temperature

5: TBAF / tetrahydrofuran / 3 h / Ambient temperature

6: 3 h / Ambient temperature

7: 92 percent / DMAP / CH₂Cl₂ / 15 h / Ambient temperature

With dmap; sodium tetrahydroborate; nickel boride; tetrabutyl ammonium fluoride; hydrogen; acetic acid; dicyclohexyl-carbodiimide; 2,4-bis(4-methylphenylthio)-1,3,2λ⁵,4λ⁵-dithiadiphosphetane-2,4-dithione; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane;