N-benzyl-2-{1-[(3,4-dimethoxyphenyl)methyl]-6-methoxy-7-(pyridin-3-ylmethoxy)-1,2,3,4-tetrahydroisoquinolin-2-yl}acetamide

Base Information

Chemical Name:N-benzyl-2-{1-[(3,4-dimethoxyphenyl)methyl]-6-methoxy-7-(pyridin-3-ylmethoxy)-1,2,3,4-tetrahydroisoquinolin-2-yl}acetamide
CAS No.:1451411-53-2
Molecular Formula:C₃₄H₃₇N₃O₅
Molecular Weight:567.685
Hs Code.:

Synonyms:N-benzyl-2-{1-[(3,4-dimethoxyphenyl)methyl]-6-methoxy-7-(pyridin-3-ylmethoxy)-1,2,3,4-tetrahydroisoquinolin-2-yl}acetamide

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Chemical Property of N-benzyl-2-{1-[(3,4-dimethoxyphenyl)methyl]-6-methoxy-7-(pyridin-3-ylmethoxy)-1,2,3,4-tetrahydroisoquinolin-2-yl}acetamide

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Technology Process of N-benzyl-2-{1-[(3,4-dimethoxyphenyl)methyl]-6-methoxy-7-(pyridin-3-ylmethoxy)-1,2,3,4-tetrahydroisoquinolin-2-yl}acetamide

There total 6 articles about N-benzyl-2-{1-[(3,4-dimethoxyphenyl)methyl]-6-methoxy-7-(pyridin-3-ylmethoxy)-1,2,3,4-tetrahydroisoquinolin-2-yl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 69966-55-8
3-picolyl bromide

: 361388-49-0
N-benzyl-2-{1-[(3,4-dimethoxyphenyl)methyl]-7-hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinolin-2-yl}acetamide

: 1451411-53-2
N-benzyl-2-{1-[(3,4-dimethoxyphenyl)methyl]-6-methoxy-7-(pyridin-3-ylmethoxy)-1,2,3,4-tetrahydroisoquinolin-2-yl}acetamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm400720h

Reference yield:

: 1477-68-5
3-Methoxytyramine hydrochloride

: 1451411-53-2
N-benzyl-2-{1-[(3,4-dimethoxyphenyl)methyl]-6-methoxy-7-(pyridin-3-ylmethoxy)-1,2,3,4-tetrahydroisoquinolin-2-yl}acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: trichlorophosphate / toluene / 2 h / 90 °C

3: sodium tetrahydroborate / methanol / 20 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

5: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With sodium tetrahydroborate; tetra-(n-butyl)ammonium iodide; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm400720h

Reference yield:

: 93-40-3
(3,4-Dimethoxyphenyl)acetic acid

: 1451411-53-2
N-benzyl-2-{1-[(3,4-dimethoxyphenyl)methyl]-6-methoxy-7-(pyridin-3-ylmethoxy)-1,2,3,4-tetrahydroisoquinolin-2-yl}acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: trichlorophosphate / toluene / 2 h / 90 °C

3: sodium tetrahydroborate / methanol / 20 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

5: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With sodium tetrahydroborate; tetra-(n-butyl)ammonium iodide; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm400720h