(1-benzyloxycarbonylamino-2-methyl-propyl)-(1-hydroxy-3-phenyl-propyl)-phosphinic acid benzyl ester

Base Information

• Chemical Name: (1-benzyloxycarbonylamino-2-methyl-propyl)-(1-hydroxy-3-phenyl-propyl)-phosphinic acid benzyl ester
• CAS No.: 853030-24-7
• Molecular Formula: C₂₈H₃₄NO₅P
• Molecular Weight: 495.555
• Mol file: 853030-24-7.mol

Synonyms:(1-benzyloxycarbonylamino-2-methyl-propyl)-(1-hydroxy-3-phenyl-propyl)-phosphinic acid benzyl ester

Chemical Property of (1-benzyloxycarbonylamino-2-methyl-propyl)-(1-hydroxy-3-phenyl-propyl)-phosphinic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1-benzyloxycarbonylamino-2-methyl-propyl)-(1-hydroxy-3-phenyl-propyl)-phosphinic acid benzyl ester

There total 2 articles about (1-benzyloxycarbonylamino-2-methyl-propyl)-(1-hydroxy-3-phenyl-propyl)-phosphinic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(1-benzyloxycarbonylamino-2-methyl-propyl)-phosphinic acid benzyl ester + 3-phenyl-propionaldehyde (104-53-0) → (1-benzyloxycarbonylamino-2-methyl-propyl)-(1-hydroxy-3-phenyl-propyl)-phosphinic acid benzyl ester (853030-24-7)

Guidance literature:

With chloro-trimethyl-silane; triethylamine; In dichloromethane; for 24h;

DOI:10.1016/j.tetlet.2005.03.083

Reference yield:

<1-<<(phenylmethoxy)carbonyl>amino>-2-methylpropyl>phosphinic acid (65577-59-5) → (1-benzyloxycarbonylamino-2-methyl-propyl)-(1-hydroxy-3-phenyl-propyl)-phosphinic acid benzyl ester (853030-24-7)

Guidance literature:

Multi-step reaction with 2 steps

1: DCC; DMAP / tetrahydrofuran / 4 h

2: 75 percent / Et₃N; trimethylsilyl chloride / CH₂Cl₂ / 24 h

With dmap; chloro-trimethyl-silane; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tetlet.2005.03.083

Reference yield: 94.0%

(1-benzyloxycarbonylamino-2-methyl-propyl)-(1-hydroxy-3-phenyl-propyl)-phosphinic acid benzyl ester (853030-24-7) → (1-amino-2-methyl-propyl)-(1-hydroxy-3-phenyl-propyl)-phosphinic acid

Guidance literature:

With hydrogen bromide; In acetic acid; at 20 ℃; for 1h;

DOI:10.1016/j.tetlet.2005.03.083

upstream raw materials:

3-phenyl-propionaldehyde

<1-<<(phenylmethoxy)carbonyl>amino>-2-methylpropyl>phosphinic acid