{2-[2-(cyclohexaneamido)-6-morpholino-9H-purin-9-yl]acetoxy}methyl pivalate

Base Information

Chemical Name:{2-[2-(cyclohexaneamido)-6-morpholino-9H-purin-9-yl]acetoxy}methyl pivalate
CAS No.:1449781-74-1
Molecular Formula:C₂₄H₃₄N₆O₆
Molecular Weight:502.571
Hs Code.:

Synonyms:{2-[2-(cyclohexaneamido)-6-morpholino-9H-purin-9-yl]acetoxy}methyl pivalate

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Chemical Property of {2-[2-(cyclohexaneamido)-6-morpholino-9H-purin-9-yl]acetoxy}methyl pivalate

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Technology Process of {2-[2-(cyclohexaneamido)-6-morpholino-9H-purin-9-yl]acetoxy}methyl pivalate

There total 6 articles about {2-[2-(cyclohexaneamido)-6-morpholino-9H-purin-9-yl]acetoxy}methyl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1255653-48-5
2-(2-(cyclohexanecarboxamido)-6-(N-morpholino)-9H-purin-9-yl)acetic acid

: 53064-79-2
iodomethyl pivaloate

: 1449781-74-1
{2-[2-(cyclohexaneamido)-6-morpholino-9H-purin-9-yl]acetoxy}methyl pivalate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 6h; Darkness;
DOI:10.1016/j.bmc.2013.04.080

Reference yield:

: 2-(N-tert-butoxycarbonyl)amino-6-chloro-9H-purine

: 1449781-74-1
{2-[2-(cyclohexaneamido)-6-morpholino-9H-purin-9-yl]acetoxy}methyl pivalate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triphenylphosphine / tetrahydrofuran / 0.03 h / 20 °C / Inert atmosphere

1.2: 0.25 h / 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.5 h / 135 °C / Sealed tube; Microwave irradiation

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.1: pyridine / 1 h / 20 °C

5.1: water; lithium hydroxide / tetrahydrofuran / 0.5 h / 20 °C

5.2: pH Ca_. 5.5

6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6 h / 20 °C / Darkness

With pyridine; water; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; 1.1: |Mitsunobu Displacement / 1.2: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2013.04.080

Reference yield:

: 1236151-75-9
ethyl 2-(2-((tert-butoxycarbonyl)amino)-6-chloro-9H-purin-9-yl)acetate

: 1449781-74-1
{2-[2-(cyclohexaneamido)-6-morpholino-9H-purin-9-yl]acetoxy}methyl pivalate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.5 h / 135 °C / Sealed tube; Microwave irradiation

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.1: pyridine / 1 h / 20 °C

4.1: water; lithium hydroxide / tetrahydrofuran / 0.5 h / 20 °C

4.2: pH Ca_. 5.5

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6 h / 20 °C / Darkness

With pyridine; water; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.04.080