5-(2-fluorobenzoyl)-2,3-dimethoxybenzonitrile

Base Information

Chemical Name:5-(2-fluorobenzoyl)-2,3-dimethoxybenzonitrile
CAS No.:125629-41-6
Molecular Formula:C₁₆H₁₂FNO₃
Molecular Weight:285.275
Hs Code.:

Synonyms:5-(2-fluorobenzoyl)-2,3-dimethoxybenzonitrile

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Chemical Property of 5-(2-fluorobenzoyl)-2,3-dimethoxybenzonitrile

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Technology Process of 5-(2-fluorobenzoyl)-2,3-dimethoxybenzonitrile

There total 10 articles about 5-(2-fluorobenzoyl)-2,3-dimethoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.9%

: 151-50-8
potassium cyanide

: 5-(2-Fluoro-benzoyl)-2,3-dimethoxy-benzenediazonium; hydrogen sulfate

: 125629-41-6
5-(2-fluorobenzoyl)-2,3-dimethoxybenzonitrile

Guidance literature:: With sodium hydrogencarbonate; copper(II) sulfate; In water; ethyl acetate; at 0 ℃; for 1.5h;
DOI:10.1002/hlca.19890720511

Reference yield:

: 1072-85-1
o-fluorobromobenzene

: 125629-41-6
5-(2-fluorobenzoyl)-2,3-dimethoxybenzonitrile

Guidance literature:: Multi-step reaction with 9 steps

1: BuLi / 1.) THF, hexane, -70 deg C, 1 h; 2.) THF, hexane, -70 deg C, 2 h, 0 deg C, 0.5 h

2: 64.7 percent / pyridinium chlorochromate / CH₂Cl₂ / 3 h / 20 °C

3: 91.8 percent / HBr/AcOH / CH₂Cl₂ / 2 h / Ambient temperature

4: 94.5 percent / 65percent HNO₃ / acetic acid / 1.5 h

5: 86.2 percent / HBr/AcOH, 48percent aq. HBr / acetic acid / 4 h / Heating

6: 91.1 percent / NaOH, Bu₄NBr / H₂O; CH₂Cl₂ / 17 h / Ambient temperature

7: 86.3 percent / SnCl₂*2H₂O / ethanol / 0.75 h / Heating

8: 2N H₂SO₄, NaNO₂ / H₂O; tetrahydrofuran / 0.33 h / 0 °C

9: 43.9 percent / 1.) CuSO₄*5H₂O, 2.) NaHCO₃ / H₂O; ethyl acetate / 1.5 h / 0 °C

With sodium hydroxide; n-butyllithium; sulfuric acid; tetrabutylammomium bromide; hydrogen bromide; nitric acid; sodium hydrogencarbonate; copper(II) sulfate; acetic acid; pyridinium chlorochromate; tin(ll) chloride; sodium nitrite; In tetrahydrofuran; ethanol; dichloromethane; water; acetic acid; ethyl acetate;
DOI:10.1002/hlca.19890720511

Reference yield:

: 2426-87-1
3-methoxy-4-(phenylmethoxy)benzaldehyde

: 125629-41-6
5-(2-fluorobenzoyl)-2,3-dimethoxybenzonitrile

Guidance literature:: Multi-step reaction with 9 steps

1: BuLi / 1.) THF, hexane, -70 deg C, 1 h; 2.) THF, hexane, -70 deg C, 2 h, 0 deg C, 0.5 h

2: 64.7 percent / pyridinium chlorochromate / CH₂Cl₂ / 3 h / 20 °C

3: 91.8 percent / HBr/AcOH / CH₂Cl₂ / 2 h / Ambient temperature

4: 94.5 percent / 65percent HNO₃ / acetic acid / 1.5 h

5: 86.2 percent / HBr/AcOH, 48percent aq. HBr / acetic acid / 4 h / Heating

6: 91.1 percent / NaOH, Bu₄NBr / H₂O; CH₂Cl₂ / 17 h / Ambient temperature

7: 86.3 percent / SnCl₂*2H₂O / ethanol / 0.75 h / Heating

8: 2N H₂SO₄, NaNO₂ / H₂O; tetrahydrofuran / 0.33 h / 0 °C

9: 43.9 percent / 1.) CuSO₄*5H₂O, 2.) NaHCO₃ / H₂O; ethyl acetate / 1.5 h / 0 °C

With sodium hydroxide; n-butyllithium; sulfuric acid; tetrabutylammomium bromide; hydrogen bromide; nitric acid; sodium hydrogencarbonate; copper(II) sulfate; acetic acid; pyridinium chlorochromate; tin(ll) chloride; sodium nitrite; In tetrahydrofuran; ethanol; dichloromethane; water; acetic acid; ethyl acetate;
DOI:10.1002/hlca.19890720511