Isobutyric acid 3-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-yl]-5-isobutyryl-6-isobutyryloxy-9-oxo-5,6,7,9-tetrahydro-3H-imidazo[1,2-a]purin-7-yl ester; compound with triethyl-amine

Base Information

• Chemical Name: Isobutyric acid 3-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-yl]-5-isobutyryl-6-isobutyryloxy-9-oxo-5,6,7,9-tetrahydro-3H-imidazo[1,2-a]purin-7-yl ester; compound with triethyl-amine
• CAS No.: 85562-03-4
• Molecular Formula: C₆H₁₅N*C₅₁H₅₆N₅O₁₃PS
• Molecular Weight: 1111.26

Synonyms:Isobutyric acid 3-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-yl]-5-isobutyryl-6-isobutyryloxy-9-oxo-5,6,7,9-tetrahydro-3H-imidazo[1,2-a]purin-7-yl ester; compound with triethyl-amine

Chemical Property of Isobutyric acid 3-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-yl]-5-isobutyryl-6-isobutyryloxy-9-oxo-5,6,7,9-tetrahydro-3H-imidazo[1,2-a]purin-7-yl ester; compound with triethyl-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Isobutyric acid 3-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-yl]-5-isobutyryl-6-isobutyryloxy-9-oxo-5,6,7,9-tetrahydro-3H-imidazo[1,2-a]purin-7-yl ester; compound with triethyl-amine

There total 3 articles about Isobutyric acid 3-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-yl]-5-isobutyryl-6-isobutyryloxy-9-oxo-5,6,7,9-tetrahydro-3H-imidazo[1,2-a]purin-7-yl ester; compound with triethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Isobutyric acid 3-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(bis-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-yl]-5-isobutyryl-6-isobutyryloxy-9-oxo-5,6,7,9-tetrahydro-3H-imidazo[1,2-a]purin-7-yl ester (85562-01-2) + triethylamine (121-44-8) → Isobutyric acid 3-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-yl]-5-isobutyryl-6-isobutyryloxy-9-oxo-5,6,7,9-tetrahydro-3H-imidazo[1,2-a]purin-7-yl ester; compound with triethyl-amine (85562-03-4) + thiophenol (108-98-5)

Guidance literature:

With hypophosphorous acid; In pyridine; at 40 ℃; for 0.333333h;

DOI:10.1016/S0040-4039(00)85820-7

Reference yield:

S,S-diphenyl N2-isobutyryl-5'-O-dimethoxytritylguanosine 3'-phosphorodithioate (85571-16-0) → Isobutyric acid 3-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-yl]-5-isobutyryl-6-isobutyryloxy-9-oxo-5,6,7,9-tetrahydro-3H-imidazo[1,2-a]purin-7-yl ester; compound with triethyl-amine (85562-03-4)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine

2: pyridine / 1 h

3: phosphinic acid / pyridine / 0.33 h / 40 °C

With hypophosphorous acid; In pyridine;

DOI:10.1016/S0040-4039(00)85820-7

Reference yield:

Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6,7-dihydroxy-5-isobutyryl-9-oxo-5,6,7,9-tetrahydro-imidazo[1,2-a]purin-3-yl)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester (85562-00-1) → Isobutyric acid 3-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-yl]-5-isobutyryl-6-isobutyryloxy-9-oxo-5,6,7,9-tetrahydro-3H-imidazo[1,2-a]purin-7-yl ester; compound with triethyl-amine (85562-03-4)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 1 h

2: phosphinic acid / pyridine / 0.33 h / 40 °C

With hypophosphorous acid; In pyridine;

DOI:10.1016/S0040-4039(00)85820-7

upstream raw materials:

Isobutyric acid 3-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(bis-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-yl]-5-isobutyryl-6-isobutyryloxy-9-oxo-5,6,7,9-tetrahydro-3H-imidazo[1,2-a]purin-7-yl ester

triethylamine

S,S-diphenyl N²-isobutyryl-5'-O-dimethoxytritylguanosine 3'-phosphorodithioate

Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6,7-dihydroxy-5-isobutyryl-9-oxo-5,6,7,9-tetrahydro-imidazo[1,2-a]purin-3-yl)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

Downstream raw materials:

C₈₇H₉₆N₁₀O₂₂P₂S₃

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 85562-03-4 Isobutyric acid 3-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-yl]-5-isobutyryl-6-isobutyryloxy-9-oxo-5,6,7,9-tetrahydro-3H-imidazo[1,2-a]purin-7-yl ester; compound with triethyl-amine

Send

Send

Metric Ton KG G Pound L ML

Send

Send