(S)-1-(3-hydroxy-propyl)-3-[4-methoxy-3-(4-methyl-pentyloxy)-phenyl]-1-(1-phenyl-ethyl)urea

Base Information

Chemical Name:(S)-1-(3-hydroxy-propyl)-3-[4-methoxy-3-(4-methyl-pentyloxy)-phenyl]-1-(1-phenyl-ethyl)urea
CAS No.:1362627-07-3
Molecular Formula:C₂₅H₃₆N₂O₄
Molecular Weight:428.572
Hs Code.:

Synonyms:(S)-1-(3-hydroxy-propyl)-3-[4-methoxy-3-(4-methyl-pentyloxy)-phenyl]-1-(1-phenyl-ethyl)urea

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Chemical Property of (S)-1-(3-hydroxy-propyl)-3-[4-methoxy-3-(4-methyl-pentyloxy)-phenyl]-1-(1-phenyl-ethyl)urea

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Technology Process of (S)-1-(3-hydroxy-propyl)-3-[4-methoxy-3-(4-methyl-pentyloxy)-phenyl]-1-(1-phenyl-ethyl)urea

There total 7 articles about (S)-1-(3-hydroxy-propyl)-3-[4-methoxy-3-(4-methyl-pentyloxy)-phenyl]-1-(1-phenyl-ethyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 4-isocycanato-1-methoxy-2-((4-methylpenyl)oxy)benzene

: 59198-54-8
N-<(S)-α-methylbenzyl>-3-aminopropan-1-ol

: 1362627-07-3
(S)-1-(3-hydroxy-propyl)-3-[4-methoxy-3-(4-methyl-pentyloxy)-phenyl]-1-(1-phenyl-ethyl)urea

Guidance literature:: In dichloromethane; at 20 ℃; for 0.166667h;

Reference yield:

: 3-(4-methyl-pentyloxy)-4-methoxy-benzoic acid

: 1362627-07-3
(S)-1-(3-hydroxy-propyl)-3-[4-methoxy-3-(4-methyl-pentyloxy)-phenyl]-1-(1-phenyl-ethyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: diphenyl phosphoryl azide; triethylamine / benzene / 5 h / 20 °C / Inert atmosphere; Reflux

2: dichloromethane / 0.17 h / Inert atmosphere

With diphenyl phosphoryl azide; triethylamine; In dichloromethane; benzene; 1: Curtius rearrangement;
DOI:10.1021/ml300005w

Reference yield:

: 626-88-0
1-bromo-5-methylpentane

: 1362627-07-3
(S)-1-(3-hydroxy-propyl)-3-[4-methoxy-3-(4-methyl-pentyloxy)-phenyl]-1-(1-phenyl-ethyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 12 h / Inert atmosphere; Reflux

2: sodium dihydrogenphosphate; sodium chlorite; dihydrogen peroxide / water; acetonitrile / 0 - 10 °C

3: diphenyl phosphoryl azide; triethylamine / benzene / 5 h / 20 °C / Inert atmosphere; Reflux

4: dichloromethane / 0.17 h / Inert atmosphere

With sodium chlorite; sodium dihydrogenphosphate; diphenyl phosphoryl azide; dihydrogen peroxide; potassium carbonate; triethylamine; In dichloromethane; water; acetone; acetonitrile; benzene; 3: Curtius rearrangement;
DOI:10.1021/ml300005w