(+)-(1R,5R)-5-Isopropenyl-2-methylcyclohex-2-enylacetic acid

Base Information

• Chemical Name: (+)-(1R,5R)-5-Isopropenyl-2-methylcyclohex-2-enylacetic acid
• CAS No.: 204526-19-2
• Molecular Formula: C₁₂H₁₈O₂
• Molecular Weight: 194.274
• Mol file: 204526-19-2.mol

Synonyms:(+)-(1R,5R)-5-Isopropenyl-2-methylcyclohex-2-enylacetic acid

Chemical Property of (+)-(1R,5R)-5-Isopropenyl-2-methylcyclohex-2-enylacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-(1R,5R)-5-Isopropenyl-2-methylcyclohex-2-enylacetic acid

There total 10 articles about (+)-(1R,5R)-5-Isopropenyl-2-methylcyclohex-2-enylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

((1R,5R)-5-Isopropenyl-2-methyl-cyclohex-2-enyl)-acetic acid ethyl ester → (+)-(1R,5R)-5-Isopropenyl-2-methylcyclohex-2-enylacetic acid (204526-19-2)

Guidance literature:

With potassium hydroxide; In methanol; water; for 1h; Ambient temperature;

DOI:10.1016/0040-4039(95)01625-R

Reference yield:

(+)-trans-carveol (2102-58-1,22567-18-6,20307-86-2) → (+)-(1R,5R)-5-Isopropenyl-2-methylcyclohex-2-enylacetic acid (204526-19-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / EtCOOH / 24 h / 140 °C

2: 75 percent / NaOH / methanol / 2 h / Heating

With sodium hydroxide; propionic acid; In methanol;

DOI:10.1021/jo010527+

Reference yield:

(1R,4R,6R)-4-isopropenyl-1-methyl-7-oxabicyclo[4.1.0]heptan-2-one (36616-60-1) → (+)-(1R,5R)-5-Isopropenyl-2-methylcyclohex-2-enylacetic acid (204526-19-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent / NH₂NH₂*H₂O / various solvent(s) / 24 h / Ambient temperature

2: 85 percent / propionic acid / 24 h / 140 °C

3: 99 percent / 2 M KOH / methanol; H₂O / 1 h / Ambient temperature

With potassium hydroxide; hydrazine hydrate; In methanol; water; propionic acid;

DOI:10.1016/0040-4039(95)01625-R

upstream raw materials:

(+)-trans-carveol

Triethyl orthoacetate

(4R,6R)-carveol

(R)-Carvone

Downstream raw materials:

(1'R,5'R,1''S)-N-(1''-phenylethyl)-2-[2'-methyl-5'-(2-propenyl)-2'-cyclohexen-1'-yl]-acetamide

(3R,3aR,5R,7aR)-5-[(4-methylbenzene)-1-sulfonyloxy]-3,7a-dimethyl-3a,4,5,6,7,7a-hexahydro-2(3H)-benzofuranone

1-Diazo-3-((1R,5S)-5-isopropenyl-2-methyl-cyclohex-2-enyl)-propan-2-one

(3R,3aR,5R,7aR)-5-(p-toluenesulfonyloxy)-7a-methyl-3-(2-propenyl)-3a,4,567,7a-hexahydro-2(3H)-benzofuranone