(2S)-3-benzoyl-2-(toluene-4-sulfonylamino)-propionic acid ethyl ester

Base Information

• Chemical Name: (2S)-3-benzoyl-2-(toluene-4-sulfonylamino)-propionic acid ethyl ester
• CAS No.: 207230-32-8
• Molecular Formula: C₁₉H₂₁NO₅S
• Molecular Weight: 375.445
• Mol file: 207230-32-8.mol

Synonyms:(2S)-3-benzoyl-2-(toluene-4-sulfonylamino)-propionic acid ethyl ester

Chemical Property of (2S)-3-benzoyl-2-(toluene-4-sulfonylamino)-propionic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (2S)-3-benzoyl-2-(toluene-4-sulfonylamino)-propionic acid ethyl ester

There total 10 articles about (2S)-3-benzoyl-2-(toluene-4-sulfonylamino)-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-styrenyloxytrimethylsilane (13735-81-4) + (E)-ethyl 2-(tosylimino)acetate (83670-53-5) → (2S)-3-benzoyl-2-(toluene-4-sulfonylamino)-propionic acid ethyl ester (207230-32-8)

Guidance literature:

With (R)-Tol-BINAP-CuClO₄*(CH₃CN)2; In tetrahydrofuran; at 0 ℃; for 24h;

DOI:10.1021/ja016838j

Reference yield: 30.0%

(2S)-4-phenyl-2-(toluene-4-sulfonylamino)-pent-4-enoic acid ethyl ester (216780-98-2) → (2S)-3-benzoyl-2-(toluene-4-sulfonylamino)-propionic acid ethyl ester (207230-32-8)

Guidance literature:

With potassium permanganate; In tetrahydrofuran; water; at 45 ℃; for 0.5h;

DOI:10.1021/ja016838j

Reference yield:

1-styrenyloxytrimethylsilane (13735-81-4) + N-p-toluenesulfonylhydroxyglycine ethyl ester (223581-34-8) → (2S)-3-benzoyl-2-(toluene-4-sulfonylamino)-propionic acid ethyl ester (207230-32-8) + (R)-4-Oxo-4-phenyl-2-(toluene-4-sulfonylamino)-butyric acid ethyl ester

Guidance literature:

With (R)-Tol-BINAP*CuClO₄; In dichloromethane; for 5h; Yield given; Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;

DOI:10.1021/jo982421t

upstream raw materials:

1-styrenyloxytrimethylsilane

(E)-ethyl 2-(tosylimino)acetate

N-p-toluenesulfonylhydroxyglycine ethyl ester

ethyl 2,2-bis(4-methylphenylsulfonamido)acetate

Downstream raw materials:

(S)-2-amino-4-oxo-4-phenyl-butanoic acid