(2R)-2-<4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-4,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl>propanoic acid

Base Information

• Chemical Name: (2R)-2-<4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-4,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl>propanoic acid
• CAS No.: 174563-10-1
• Molecular Formula: C₁₄H₁₃F₄N₃O₄
• Molecular Weight: 363.269

Synonyms:(2R)-2-<4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-4,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl>propanoic acid

Chemical Property of (2R)-2-<4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-4,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl>propanoic acid

Chemical Property:

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Technology Process of (2R)-2-<4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-4,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl>propanoic acid

There total 2 articles about (2R)-2-<4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-4,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl>propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl (2R)-2-<4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-4,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl>propanoate (174563-09-8) → (2R)-2-<4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-4,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl>propanoic acid (174563-10-1)

Guidance literature:

palladium-carbon; In ethanol; water;

Reference yield:

benzyl (2R)-2-<4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-4,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl>propanoate (174563-09-8) → (2R)-2-<4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-4,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl>propanoic acid (174563-10-1) + (S)-2-{5-Oxo-4-[4-(2,2,3,3-tetrafluoro-propoxy)-phenyl]-4,5-dihydro-[1,2,4]triazol-1-yl}-propionic acid

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; under 760 Torr; Yield given; Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;

DOI:10.1248/cpb.47.360

Reference yield:

(2R)-2-<4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-4,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl>propanoic acid (174563-10-1) → (2R)-2-[4-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-4,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]propanoyl chloride (174563-11-2)

Guidance literature:

With thionyl chloride;

upstream raw materials:

benzyl (2R)-2-<4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-4,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl>propanoate

Downstream raw materials:

(2R)-2-[4-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-4,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]propanoyl chloride

2-<(1R)-2-(2,4-difluorophenyl)-2-oxo-1-methylethyl>-4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone

2-<(1R,2S)-2-(2,4-difluorophenyl)-2-formyl-2-hydroxy-1-methylethyl>-4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone

2-<(1R,2S)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-butenyl>-4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone

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