5-chloro-1-(3-fluoro-4-hydroxyphenyl)-1H-indazol-4-ol

Base Information

Chemical Name:5-chloro-1-(3-fluoro-4-hydroxyphenyl)-1H-indazol-4-ol
CAS No.:1056262-46-4
Molecular Formula:C₁₃H₈ClFN₂O₂
Molecular Weight:278.67
Hs Code.:

Synonyms:5-chloro-1-(3-fluoro-4-hydroxyphenyl)-1H-indazol-4-ol

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Chemical Property of 5-chloro-1-(3-fluoro-4-hydroxyphenyl)-1H-indazol-4-ol

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Technology Process of 5-chloro-1-(3-fluoro-4-hydroxyphenyl)-1H-indazol-4-ol

There total 5 articles about 5-chloro-1-(3-fluoro-4-hydroxyphenyl)-1H-indazol-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1056264-90-4
5-chloro-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-1H-indazol-4-ol

: 1056262-46-4
5-chloro-1-(3-fluoro-4-hydroxyphenyl)-1H-indazol-4-ol

Guidance literature:: 5-chloro-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-1H-indazol-4-ol; With boron tribromide; In dichloromethane; at -78 ℃; for 3.08333h;

With methanol; water; sodium hydrogencarbonate; In dichloromethane; pH=7;

Reference yield:

: 1056264-66-4
2-bromo-3-chloro-6-fluorobenzaldehyde

: 1056262-46-4
5-chloro-1-(3-fluoro-4-hydroxyphenyl)-1H-indazol-4-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-methoxylamine hydrochloride; potassium carbonate / 1,2-dimethoxyethane / 5 h / 40 °C

1.2: 21 h / 100 °C

2.1: pyridine / copper diacetate / dichloromethane / 120 h / Molecular sieve

3.1: potassium hydroxide; water / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / 1,4-dioxane / 3 h / 90 °C

4.1: boron tribromide / dichloromethane / 3.08 h / -78 °C

4.2: pH 7

With pyridine; potassium hydroxide; water; N-methoxylamine hydrochloride; boron tribromide; potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper diacetate; tert-butyl XPhos; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane;

Reference yield:

: 1056264-74-4
4-bromo-5-chloro-1H-indazole

: 1056262-46-4
5-chloro-1-(3-fluoro-4-hydroxyphenyl)-1H-indazol-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / copper diacetate / dichloromethane / 120 h / Molecular sieve

2.1: potassium hydroxide; water / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / 1,4-dioxane / 3 h / 90 °C

3.1: boron tribromide / dichloromethane / 3.08 h / -78 °C

3.2: pH 7

With pyridine; potassium hydroxide; water; boron tribromide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper diacetate; tert-butyl XPhos; In 1,4-dioxane; dichloromethane;