tert-butyl L-4-amino(9-fluorenylmethoxycarbonyl)phenylalanyl-L-phenylalaninate

Base Information

Chemical Name:tert-butyl L-4-amino(9-fluorenylmethoxycarbonyl)phenylalanyl-L-phenylalaninate
CAS No.:320782-44-3
Molecular Formula:C₃₇H₃₉N₃O₅
Molecular Weight:605.734
Hs Code.:

Synonyms:tert-butyl L-4-amino(9-fluorenylmethoxycarbonyl)phenylalanyl-L-phenylalaninate

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Chemical Property of tert-butyl L-4-amino(9-fluorenylmethoxycarbonyl)phenylalanyl-L-phenylalaninate

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Technology Process of tert-butyl L-4-amino(9-fluorenylmethoxycarbonyl)phenylalanyl-L-phenylalaninate

There total 1 articles about tert-butyl L-4-amino(9-fluorenylmethoxycarbonyl)phenylalanyl-L-phenylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 320782-43-2
tert-butyl tert-butyloxycarbonyl-L-4-amino(9-fluorenylmethoxycarbonyl)phenylalanyl-L-phenylalaninate

: 320782-44-3
tert-butyl L-4-amino(9-fluorenylmethoxycarbonyl)phenylalanyl-L-phenylalaninate

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; toluene; for 3h;
DOI:10.1021/jm000345s

Reference yield:

: 320782-44-3
tert-butyl L-4-amino(9-fluorenylmethoxycarbonyl)phenylalanyl-L-phenylalaninate

: L-tyrosyl-L-1,2,3,4-tetrahydroisoquinoline-3-carbonyl-L-4-aminophenylalanyl-L-phenylalanine

Guidance literature:: Multi-step reaction with 3 steps

1: PyBOP; DIPEA / dimethylformamide

2: piperidine / dimethylformamide / 1.5 h / 20 °C

3: 80 percent / TFA; anisole / 1 h / 20 °C

With piperidine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; methoxybenzene; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm000345s

Reference yield:

: 320782-44-3
tert-butyl L-4-amino(9-fluorenylmethoxycarbonyl)phenylalanyl-L-phenylalaninate

: L-tyrosyl-L-1,2,3,4-tetrahydroisoquinoline-3-carbonyl-L-4-isothiocyanatophenylalanyl-L-phenylalanine

Guidance literature:: Multi-step reaction with 4 steps

1: PyBOP; DIPEA / dimethylformamide

2: piperidine / dimethylformamide / 1.5 h / 20 °C

3: DIPEA / CH₂Cl₂ / 1.5 h / 20 °C

4: 65 percent / TFA; anisole / 1 h / 20 °C

With piperidine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; methoxybenzene; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm000345s