3,5-dichloro-4-[7-(4-trifluoromethyl-phenylamino)-thiazolo[5,4-d]pyrimidin-2-ylamino]-benzaldehyde

Base Information

• Chemical Name: 3,5-dichloro-4-[7-(4-trifluoromethyl-phenylamino)-thiazolo[5,4-d]pyrimidin-2-ylamino]-benzaldehyde
• CAS No.: 1000709-80-7
• Molecular Formula: C₁₉H₁₀Cl₂F₃N₅OS
• Molecular Weight: 484.289

Synonyms:3,5-dichloro-4-[7-(4-trifluoromethyl-phenylamino)-thiazolo[5,4-d]pyrimidin-2-ylamino]-benzaldehyde

Chemical Property of 3,5-dichloro-4-[7-(4-trifluoromethyl-phenylamino)-thiazolo[5,4-d]pyrimidin-2-ylamino]-benzaldehyde

Chemical Property:

Purity/Quality:

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Technology Process of 3,5-dichloro-4-[7-(4-trifluoromethyl-phenylamino)-thiazolo[5,4-d]pyrimidin-2-ylamino]-benzaldehyde

There total 1 articles about 3,5-dichloro-4-[7-(4-trifluoromethyl-phenylamino)-thiazolo[5,4-d]pyrimidin-2-ylamino]-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Example 234 (1000709-17-0) → 3,5-dichloro-4-[7-(4-trifluoromethyl-phenylamino)-thiazolo[5,4-d]pyrimidin-2-ylamino]-benzaldehyde (1000709-80-7)

Guidance literature:

Example 234; With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at -20 - 20 ℃; for 4h;

With water; Rochelle's salt; In tetrahydrofuran; toluene; for 1h;

Reference yield: 34.0%

azetidine (503-29-7) + 3,5-dichloro-4-[7-(4-trifluoromethyl-phenylamino)-thiazolo[5,4-d]pyrimidin-2-ylamino]-benzaldehyde (1000709-80-7) → Example 239

Guidance literature:

azetidine; 3,5-dichloro-4-[7-(4-trifluoromethyl-phenylamino)-thiazolo[5,4-d]pyrimidin-2-ylamino]-benzaldehyde; With sodium tris(acetoxy)borohydride; In dichloromethane; for 5h;

With water; sodium hydrogencarbonate; In dichloromethane;

Reference yield:

morpholine (110-91-8,99108-56-2) + 3,5-dichloro-4-[7-(4-trifluoromethyl-phenylamino)-thiazolo[5,4-d]pyrimidin-2-ylamino]-benzaldehyde (1000709-80-7) → Example 238

Guidance literature:

morpholine; 3,5-dichloro-4-[7-(4-trifluoromethyl-phenylamino)-thiazolo[5,4-d]pyrimidin-2-ylamino]-benzaldehyde; With sodium tris(acetoxy)borohydride; In dichloromethane; for 5h;

With water; sodium hydrogencarbonate; In dichloromethane;

upstream raw materials:

Example 234

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