alpha-Bromo-beta-phenylpropiophenone

Base Information

• Chemical Name: alpha-Bromo-beta-phenylpropiophenone
• CAS No.: 51012-66-9
• Molecular Formula: C15H13BrO
• Molecular Weight: 289.172
• DSSTox Substance ID: DTXSID90965290
• Nikkaji Number: J2.713.973F
• Mol file: 51012-66-9.mol

Synonyms:alpha-Bromo-beta-phenylpropiophenone;BRN 2106514;2-bromo-1,3-diphenylpropan-1-one;Propiophenone, alpha-bromo-beta-phenyl-;3-07-00-02153 (Beilstein Handbook Reference);51012-66-9;SCHEMBL4257686;C15-H13-Br-O;DTXSID90965290;PAYVMUYAPQRGML-UHFFFAOYSA-N;1-Propanone, 2-bromo-1,3-diphenyl-;LS-125070

Chemical Property of alpha-Bromo-beta-phenylpropiophenone

Chemical Property:

• Vapor Pressure: 7.34E-06mmHg at 25°C
• Boiling Point: 376.3°C at 760 mmHg
• Flash Point: 57.1°C
• Density: 1.365g/cm³
• XLogP3: 4.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 288.01498
• Heavy Atom Count: 17
• Complexity: 239

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CC(C(=O)C2=CC=CC=C2)Br

Technology Process of alpha-Bromo-beta-phenylpropiophenone

There total 16 articles about alpha-Bromo-beta-phenylpropiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-benzyl-2-bromo-1,3-diphenylpropane-1,3-dione → 2-benzyl-2-bromoacetophenone (51012-66-9)

Guidance literature:

With silica-supported sulfuric acid; In 1,2-dichloro-ethane; at 80 ℃; for 1h;

DOI:10.1246/cl.2011.484

Reference yield: 88.0%

1,3-diphenylpropene (3412-44-0,1138-83-6,5209-18-7) → 2-benzyl-2-bromoacetophenone (51012-66-9)

Guidance literature:

With N-Bromosuccinimide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; at 25 - 35 ℃; for 3h; regioselective reaction;

DOI:10.1016/j.tetlet.2009.03.032

Reference yield: 87.0%

dihydrochalcone (1083-30-3) → 2-benzyl-2-bromoacetophenone (51012-66-9)

Guidance literature:

With bromine; In acetic acid; at 50 ℃;

DOI:10.1007/BF00486920

upstream raw materials:

dihydrochalcone

1-(2-(phenylmethyl)phenyl)ethanone

benzalacetophenone

dihydrocinnamonitrile

Downstream raw materials:

1,3-diphenyl-2-piperidin-1-yl-propan-1-one

trans-(2S,3R)-epoxy-1,3-diphenylpropan-1-one

1,3-diphenyl-2-(methylthio)-1-propanone

1,3-diphenyl-1-(phenylamino)propan-2-one