C₅₄H₉₄N₄O₁₄

Base Information

• Chemical Name: C₅₄H₉₄N₄O₁₄
• CAS No.: 1052120-09-8
• Molecular Formula: C₅₄H₉₄N₄O₁₄
• Molecular Weight: 1023.36
• Mol file: 1052120-09-8.mol

Synonyms:C₅₄H₉₄N₄O₁₄

Chemical Property of C₅₄H₉₄N₄O₁₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₄H₉₄N₄O₁₄

There total 8 articles about C₅₄H₉₄N₄O₁₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

4-(4-morpholin-4-yl-phenyl)butylamine (1052138-90-5) + 3'-N-propylcarboxylic acid of azithromycin (1052138-65-4) → C54H94N4O14 (1052120-09-8)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 4 - 6h;

Reference yield:

1-(4-azidobutyl)-4-iodobenzene (1052138-83-6) → C54H94N4O14 (1052120-09-8)

Guidance literature:

Multi-step reaction with 3 steps

1: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 4 h / 110 °C

2: hydrogen / palladium on activated charcoal / methanol

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 - 6 h / 0 - 20 °C

With copper(l) iodide; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; L-proline; palladium on activated charcoal; In methanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

methanesulfonic acid 4-(4-iodophenyl)butyl ester (1052138-82-5) → C54H94N4O14 (1052120-09-8)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium azide / N,N-dimethyl-formamide / 6 h / 20 °C

2: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 4 h / 110 °C

3: hydrogen / palladium on activated charcoal / methanol

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 - 6 h / 0 - 20 °C

With copper(l) iodide; sodium azide; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; L-proline; palladium on activated charcoal; In methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

upstream raw materials:

4-(4-morpholin-4-yl-phenyl)butylamine

3'-N-propylcarboxylic acid of azithromycin

4-(4-iodophenyl)butan-1-ol

1-(4-azidobutyl)-4-iodobenzene