1-butyl-2-(ethoxycarbonyl)-N-benzyl-N-pent-4-enylaziridine-2-carboxamide

Base Information

Chemical Name:1-butyl-2-(ethoxycarbonyl)-N-benzyl-N-pent-4-enylaziridine-2-carboxamide
CAS No.:145126-89-2
Molecular Formula:C₂₂H₃₂N₂O₃
Molecular Weight:372.508
Hs Code.:

Synonyms:1-butyl-2-(ethoxycarbonyl)-N-benzyl-N-pent-4-enylaziridine-2-carboxamide

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Chemical Property of 1-butyl-2-(ethoxycarbonyl)-N-benzyl-N-pent-4-enylaziridine-2-carboxamide

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Technology Process of 1-butyl-2-(ethoxycarbonyl)-N-benzyl-N-pent-4-enylaziridine-2-carboxamide

There total 8 articles about 1-butyl-2-(ethoxycarbonyl)-N-benzyl-N-pent-4-enylaziridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 54436-58-7
N-benzylpent-4-en-1-amine

: 156641-24-6
1-Butyl-2-chlorocarbonyl-aziridine-2-carboxylic acid ethyl ester

: 145126-89-2
1-butyl-2-(ethoxycarbonyl)-N-benzyl-N-pent-4-enylaziridine-2-carboxamide

Guidance literature:: With sodium hydroxide; In diethyl ether; dichloromethane; for 0.5h; Ambient temperature;
DOI:10.1021/jo00052a015

Reference yield:

: 591-80-0
pent-4-enoic acid

: 145126-89-2
1-butyl-2-(ethoxycarbonyl)-N-benzyl-N-pent-4-enylaziridine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1) 2-(chloromethyl)pyridinium iodide, 2) diisopropylethylamine / 1) CH₂Cl₂, 2) 0 deg to room temperature, 46 h

2: 92 percent / DIBAL / tetrahydrofuran; toluene / a) room temperature, 1 h, b) 50 deg C, 90 min

3: 69 percent / 15percent aq. NaOH / CH₂Cl₂; diethyl ether / 0.5 h / Ambient temperature

With sodium hydroxide; 2-chloromethylpyridinium iodide; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;
DOI:10.1021/jo00052a015

Reference yield:

: 53084-38-1
diethyl α,β-dibromomethylmalonate

: 145126-89-2
1-butyl-2-(ethoxycarbonyl)-N-benzyl-N-pent-4-enylaziridine-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / Et₃N / acetonitrile / 5 h / Ambient temperature

2: NaOH / ethanol / Ambient temperature; overnight

3: SOCl₂ / CH₂Cl₂ / 1.5 h / -78 - -30 °C

4: 69 percent / 15percent aq. NaOH / CH₂Cl₂; diethyl ether / 0.5 h / Ambient temperature

With sodium hydroxide; thionyl chloride; triethylamine; In diethyl ether; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jo00052a015