4-[5-cyano-7-(2-fluorophenyl)-1,3-benzoxazol-2-yl]-N-({1-[4-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-yl}methyl)benzamide

Base Information

Chemical Name:4-[5-cyano-7-(2-fluorophenyl)-1,3-benzoxazol-2-yl]-N-({1-[4-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-yl}methyl)benzamide
CAS No.:1093397-33-1
Molecular Formula:C₃₂H₂₄F₄N₆O₂
Molecular Weight:600.575
Hs Code.:

Synonyms:4-[5-cyano-7-(2-fluorophenyl)-1,3-benzoxazol-2-yl]-N-({1-[4-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-yl}methyl)benzamide

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Chemical Property of 4-[5-cyano-7-(2-fluorophenyl)-1,3-benzoxazol-2-yl]-N-({1-[4-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-yl}methyl)benzamide

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Technology Process of 4-[5-cyano-7-(2-fluorophenyl)-1,3-benzoxazol-2-yl]-N-({1-[4-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-yl}methyl)benzamide

There total 8 articles about 4-[5-cyano-7-(2-fluorophenyl)-1,3-benzoxazol-2-yl]-N-({1-[4-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-yl}methyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1093397-29-5
5-amino-2'-fluoro-6-hydroxybiphenyl-3-carbonitrile

: C₁₉H₁₈ClF₃N₄O₂

: 1093397-33-1
4-[5-cyano-7-(2-fluorophenyl)-1,3-benzoxazol-2-yl]-N-({1-[4-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-yl}methyl)benzamide

Guidance literature:: 5-amino-2'-fluoro-6-hydroxybiphenyl-3-carbonitrile; C₁₉H₁₈ClF₃N₄O₂; In 1,4-dioxane; at 80 ℃; for 1h;

With toluene-4-sulfonic acid; In toluene; at 140 ℃; for 15h;

Reference yield:

: 1993-03-9
o-fluorophenylboronic acid

: 1093397-33-1
4-[5-cyano-7-(2-fluorophenyl)-1,3-benzoxazol-2-yl]-N-({1-[4-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-yl}methyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / palladium diacetate / water; acetone / 18 h / 60 °C

2.1: pyrographite; hydrazine / iron(III) chloride hexahydrate / methanol / 2 h / 70 °C / Inert atmosphere

3.1: 1,4-dioxane / 1 h / 80 °C

3.2: 15 h / 140 °C

With potassium carbonate; pyrographite; hydrazine; iron(III) chloride hexahydrate; palladium diacetate; In 1,4-dioxane; methanol; water; acetone;

Reference yield:

: 1689-89-0
nitroxynil

: 1093397-33-1
4-[5-cyano-7-(2-fluorophenyl)-1,3-benzoxazol-2-yl]-N-({1-[4-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-yl}methyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / palladium diacetate / water; acetone / 18 h / 60 °C

2.1: pyrographite; hydrazine / iron(III) chloride hexahydrate / methanol / 2 h / 70 °C / Inert atmosphere

3.1: 1,4-dioxane / 1 h / 80 °C

3.2: 15 h / 140 °C

With potassium carbonate; pyrographite; hydrazine; iron(III) chloride hexahydrate; palladium diacetate; In 1,4-dioxane; methanol; water; acetone;