(4R,4aS)-4-[2-[di(propan-2-yl)amino]ethyl]-1-methyl-4-phenyl-5,6,7,8-tetrahydro-4aH-pyrido[1,2-c]pyrimidin-3-one

Base Information

Chemical Name:(4R,4aS)-4-[2-[di(propan-2-yl)amino]ethyl]-1-methyl-4-phenyl-5,6,7,8-tetrahydro-4aH-pyrido[1,2-c]pyrimidin-3-one
CAS No.:96914-40-8
Molecular Formula:C23H35N3O
Molecular Weight:369.5435
Hs Code.:

Synonyms:4-(2-(bis(1-methylethyl)amino)ethyl)-4,4a,5,6,7,8-hexahydro-1-methyl-4-phenyl-3H-pyrido(1,2-c)pyrimidin-3-one;actisomide;SC 36602;SC-36602

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R,4aS)-4-[2-[di(propan-2-yl)amino]ethyl]-1-methyl-4-phenyl-5,6,7,8-tetrahydro-4aH-pyrido[1,2-c]pyrimidin-3-one

Chemical Property:

Vapor Pressure:3.77E-09mmHg at 25°C
Boiling Point:473.9°C at 760 mmHg
Flash Point:240.4°C
PSA：35.91000
Density:1.08g/cm³
LogP:3.61990
XLogP3:3.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:369.278012748
Heavy Atom Count:27
Complexity:542

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NC(=O)C(C2N1CCCC2)(CCN(C(C)C)C(C)C)C3=CC=CC=C3
Isomeric SMILES:CC1=NC(=O)[C@]([C@H]2N1CCCC2)(CCN(C(C)C)C(C)C)C3=CC=CC=C3

Technology Process of (4R,4aS)-4-[2-[di(propan-2-yl)amino]ethyl]-1-methyl-4-phenyl-5,6,7,8-tetrahydro-4aH-pyrido[1,2-c]pyrimidin-3-one

There total 3 articles about (4R,4aS)-4-[2-[di(propan-2-yl)amino]ethyl]-1-methyl-4-phenyl-5,6,7,8-tetrahydro-4aH-pyrido[1,2-c]pyrimidin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74427-45-5,74464-83-8,74464-84-9,3737-09-5
disopyramide

: 96914-40-8
(4R,4aS)-4-(2-Diisopropylamino-ethyl)-1-methyl-4-phenyl-4,4a,5,6,7,8-hexahydro-pyrido[1,2-c]pyrimidin-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / H₂SO₄, H₂ / 5percent PtO₂/C / H₂O / 4 h / 75 °C / 3102.9 Torr

2: CH₂Cl₂ / 20 h / Ambient temperature

3: KOH / dimethylsulfoxide / 2 h

With potassium hydroxide; sulfuric acid; hydrogen; PtO₂/C; In dichloromethane; water; dimethyl sulfoxide;
DOI:10.1021/jm00147a029

Reference yield:

: 108438-25-1
1-acetyl-α-[2-[bis(1-methylethyl)amino]ethyl]-α-phenyl-2-piperidineacetamide

: 96914-40-8
(4R,4aS)-4-(2-Diisopropylamino-ethyl)-1-methyl-4-phenyl-4,4a,5,6,7,8-hexahydro-pyrido[1,2-c]pyrimidin-3-one

Guidance literature:: With potassium hydroxide; In dimethyl sulfoxide; for 2h; Yield given;
DOI:10.1021/jm00147a029

Reference yield:

: 107256-81-5
α-[2-[bis(1-methylethyl)amino]ethyl]-α-phenyl-2-piperidineacetamide

: 96914-40-8
(4R,4aS)-4-(2-Diisopropylamino-ethyl)-1-methyl-4-phenyl-4,4a,5,6,7,8-hexahydro-pyrido[1,2-c]pyrimidin-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: CH₂Cl₂ / 20 h / Ambient temperature

2: KOH / dimethylsulfoxide / 2 h

With potassium hydroxide; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm00147a029