ethyl 1-{2-[2,2,2-tris(4-methoxyphenyl)ethoxy]ethyl}piperidine-3-carboxylate

Base Information

Chemical Name:ethyl 1-{2-[2,2,2-tris(4-methoxyphenyl)ethoxy]ethyl}piperidine-3-carboxylate
CAS No.:1392206-61-9
Molecular Formula:C₃₃H₄₁NO₆
Molecular Weight:547.692
Hs Code.:

Synonyms:ethyl 1-{2-[2,2,2-tris(4-methoxyphenyl)ethoxy]ethyl}piperidine-3-carboxylate

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Chemical Property of ethyl 1-{2-[2,2,2-tris(4-methoxyphenyl)ethoxy]ethyl}piperidine-3-carboxylate

Chemical Property:

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Technology Process of ethyl 1-{2-[2,2,2-tris(4-methoxyphenyl)ethoxy]ethyl}piperidine-3-carboxylate

There total 3 articles about ethyl 1-{2-[2,2,2-tris(4-methoxyphenyl)ethoxy]ethyl}piperidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1392206-31-3
2-[2,2,2-tris(4-methoxyphenyl)ethoxy]ethanol

: 71962-74-8
Ethyl nipecotate

: 1392206-61-9
ethyl 1-{2-[2,2,2-tris(4-methoxyphenyl)ethoxy]ethyl}piperidine-3-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; propiononitrile; (cyanomethyl)trimethyl-phosphonium iodide; at 90 ℃; for 2h;
DOI:10.1002/cmdc.201200126

Reference yield:

: 1392206-24-4
2,2,2-tris(4-methoxyphenyl)ethanol

: 1392206-61-9
ethyl 1-{2-[2,2,2-tris(4-methoxyphenyl)ethoxy]ethyl}piperidine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C

1.2: 19 h / -78 - 20 °C

2.1: tetrahydrofuran; diethyl ether; hexane / 24 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; propiononitrile; (cyanomethyl)trimethyl-phosphonium iodide / 2 h / 90 °C

With n-butyllithium; N-ethyl-N,N-diisopropylamine; propiononitrile; (cyanomethyl)trimethyl-phosphonium iodide; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1002/cmdc.201200126

Reference yield:

: 95431-48-4
4,4',4''-trimethoxytriphenylacetic acid

: 1392206-61-9
ethyl 1-{2-[2,2,2-tris(4-methoxyphenyl)ethoxy]ethyl}piperidine-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C

2.2: 19 h / -78 - 20 °C

3.1: tetrahydrofuran; diethyl ether; hexane / 24 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; propiononitrile; (cyanomethyl)trimethyl-phosphonium iodide / 2 h / 90 °C

With lithium aluminium tetrahydride; n-butyllithium; N-ethyl-N,N-diisopropylamine; propiononitrile; (cyanomethyl)trimethyl-phosphonium iodide; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1002/cmdc.201200126