methyl N-tert-butoxycarbonyl-N'-(2'',4''-dimethoxybenzyl)-(S)-alanyl-(S)-tryptophanate

Base Information

Chemical Name:methyl N-tert-butoxycarbonyl-N'-(2'',4''-dimethoxybenzyl)-(S)-alanyl-(S)-tryptophanate
CAS No.:300766-84-1
Molecular Formula:C₂₉H₃₇N₃O₇
Molecular Weight:539.629
Hs Code.:

Synonyms:methyl N-tert-butoxycarbonyl-N'-(2'',4''-dimethoxybenzyl)-(S)-alanyl-(S)-tryptophanate

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Chemical Property of methyl N-tert-butoxycarbonyl-N'-(2'',4''-dimethoxybenzyl)-(S)-alanyl-(S)-tryptophanate

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Technology Process of methyl N-tert-butoxycarbonyl-N'-(2'',4''-dimethoxybenzyl)-(S)-alanyl-(S)-tryptophanate

There total 4 articles about methyl N-tert-butoxycarbonyl-N'-(2'',4''-dimethoxybenzyl)-(S)-alanyl-(S)-tryptophanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 15761-38-3
L-N-Boc-Ala

: 168766-64-1
methyl (S)-N'-(2,4-dimethoxybenzyl)tryptophanate

: 300766-84-1
methyl N-tert-butoxycarbonyl-N'-(2'',4''-dimethoxybenzyl)-(S)-alanyl-(S)-tryptophanate

: methyl N-tert-butoxycarbonyl-N'-(2'',4''-dimethoxybenzyl)-(S)-alanyl-(R)-tryptophanate

Guidance literature:: With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 20 ℃; for 44h;
DOI:10.3987/com-00-8942

Reference yield:

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 300766-84-1
methyl N-tert-butoxycarbonyl-N'-(2'',4''-dimethoxybenzyl)-(S)-alanyl-(S)-tryptophanate

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / Na₂SO₄ / benzene / 14 h / 20 °C

2: 87 percent / NaBH₄ / methanol / 15 h / 20 °C

3: 55 percent / DCC / tetrahydrofuran / 44 h / 20 °C

With sodium tetrahydroborate; sodium sulfate; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; benzene; 1: Condensation / 2: Reduction / 3: Acylation;
DOI:10.3987/com-00-8942

Reference yield:

: methyl (S)-N'-(2'',4''-dimethoxybenzyliden)tryptophanate

: 300766-84-1
methyl N-tert-butoxycarbonyl-N'-(2'',4''-dimethoxybenzyl)-(S)-alanyl-(S)-tryptophanate

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / NaBH₄ / methanol / 15 h / 20 °C

2: 55 percent / DCC / tetrahydrofuran / 44 h / 20 °C

With sodium tetrahydroborate; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; 1: Reduction / 2: Acylation;
DOI:10.3987/com-00-8942