Technology Process of methyl 4-[(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)methyl]benzoate
There total 7 articles about methyl 4-[(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)methyl]benzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: thionyl chloride / benzene / 1 h / Heating
2: triethylamine / diethyl ether / 16 h / 20 °C
3: 910 mg / silver(I) acetate / dioxane; H2O / 1.5 h / Heating
4: thionyl chloride / benzene / 1 h / Heating
5: triethylamine / diethyl ether / 1 h / 20 °C
6: 640 mg / hydrochloric acid / diethyl ether / 1 h / 70 - 80 °C
7: 27 percent / dimethylformamide / 48 h / 50 - 60 °C
With
hydrogenchloride; thionyl chloride; silver(I) acetate; triethylamine;
In
1,4-dioxane; diethyl ether; water; N,N-dimethyl-formamide; benzene;
2: Arndt-Eistert synthesis / 3: Arndt-Eistert rearrangement;
DOI:10.1016/j.bmc.2006.08.029
- Guidance literature:
-
Multi-step reaction with 4 steps
1: thionyl chloride / benzene / 1 h / Heating
2: triethylamine / diethyl ether / 1 h / 20 °C
3: 640 mg / hydrochloric acid / diethyl ether / 1 h / 70 - 80 °C
4: 27 percent / dimethylformamide / 48 h / 50 - 60 °C
With
hydrogenchloride; thionyl chloride; triethylamine;
In
diethyl ether; N,N-dimethyl-formamide; benzene;
DOI:10.1016/j.bmc.2006.08.029