(4R,5S)-2,2-Dioxo-5-phenyl-2λ⁶-[1,3,2]dioxathiolane-4-carboxylic acid benzyl ester

Base Information

• Chemical Name: (4R,5S)-2,2-Dioxo-5-phenyl-2λ⁶-[1,3,2]dioxathiolane-4-carboxylic acid benzyl ester
• CAS No.: 405304-73-6
• Molecular Formula: C₁₆H₁₄O₆S
• Molecular Weight: 334.35

Synonyms:(4R,5S)-2,2-Dioxo-5-phenyl-2λ⁶-[1,3,2]dioxathiolane-4-carboxylic acid benzyl ester

Chemical Property of (4R,5S)-2,2-Dioxo-5-phenyl-2λ⁶-[1,3,2]dioxathiolane-4-carboxylic acid benzyl ester

Chemical Property:

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Technology Process of (4R,5S)-2,2-Dioxo-5-phenyl-2λ⁶-[1,3,2]dioxathiolane-4-carboxylic acid benzyl ester

There total 5 articles about (4R,5S)-2,2-Dioxo-5-phenyl-2λ⁶-[1,3,2]dioxathiolane-4-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(4R,5S)-2-Oxo-5-phenyl-2λ4-[1,3,2]dioxathiolane-4-carboxylic acid benzyl ester (405304-72-5) → (4R,5S)-2,2-Dioxo-5-phenyl-2λ6-[1,3,2]dioxathiolane-4-carboxylic acid benzyl ester (405304-73-6)

Guidance literature:

With ruthenium trichloride; sodium periodate; In water; acetonitrile; at 20 ℃; for 1h;

DOI:10.1021/jo010860d

Reference yield:

2-oxo-5-phenyl-2λ4-[1,3,2]dioxathiolane-4-carboxylic acid benzyl ester → (4R,5S)-2,2-Dioxo-5-phenyl-2λ6-[1,3,2]dioxathiolane-4-carboxylic acid benzyl ester (405304-73-6)

Guidance literature:

With sodium periodate; ruthenium trichloride; In tetrachloromethane; water; acetonitrile; at 20 ℃; for 1h;

DOI:10.1021/jo011172x

Reference yield:

benzyl 2,3-dihydroxy-3-phenylpropionate (125559-27-5,125559-28-6,139165-61-0) → (4R,5S)-2,2-Dioxo-5-phenyl-2λ6-[1,3,2]dioxathiolane-4-carboxylic acid benzyl ester (405304-73-6)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂; triethylamine / CH₂Cl₂ / 0.08 h / 0 °C

2: 1.49 g / NaIO₄ / RuCl₃ / acetonitrile; H₂O; CCl₄ / 1 h / 20 °C

With sodium periodate; thionyl chloride; triethylamine; ruthenium trichloride; In tetrachloromethane; dichloromethane; water; acetonitrile;

DOI:10.1021/jo011172x

upstream raw materials:

(4R,5S)-2-Oxo-5-phenyl-2λ⁴-[1,3,2]dioxathiolane-4-carboxylic acid benzyl ester

benzyl 2,3-dihydroxy-3-phenylpropionate

(E)-cinnamic acid benzyl ester

(2R,3S)-2,3-dihydroxy-3-phenylpropionic acid benzyl ester

Downstream raw materials:

benzyl (2S,3R)-3-phenylaziridine-2-carboxylate

L-phenylalanine

benzyl (2S,3R)-3-phenylaziridine-2-carboxylate

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