N-(4-carbamimidoylphenyl)-2-hydroxy-2-( 4'-(trifluoromethoxy) biphenyl-3-yl)acetamide

Base Information

Chemical Name:N-(4-carbamimidoylphenyl)-2-hydroxy-2-( 4'-(trifluoromethoxy) biphenyl-3-yl)acetamide
CAS No.:1418267-24-9
Molecular Formula:C₂₂H₁₈F₃N₃O₃
Molecular Weight:429.398
Hs Code.:

Synonyms:N-(4-carbamimidoylphenyl)-2-hydroxy-2-( 4'-(trifluoromethoxy) biphenyl-3-yl)acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-carbamimidoylphenyl)-2-hydroxy-2-( 4'-(trifluoromethoxy) biphenyl-3-yl)acetamide

Chemical Property:

Purity/Quality:

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Technology Process of N-(4-carbamimidoylphenyl)-2-hydroxy-2-( 4'-(trifluoromethoxy) biphenyl-3-yl)acetamide

There total 7 articles about N-(4-carbamimidoylphenyl)-2-hydroxy-2-( 4'-(trifluoromethoxy) biphenyl-3-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1418267-55-6
2-hydroxy-N-( 4-(5-oxo-4,5-dihydro-1 ,2,4-oxadiazol-3-yl)phenyl)-2-( 4'(trifluoromethoxy)biphenyl-3-yl)acetamide

: 1418267-24-9
N-(4-carbamimidoylphenyl)-2-hydroxy-2-( 4'-(trifluoromethoxy) biphenyl-3-yl)acetamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; for 3h; under 760.051 Torr;

Reference yield:

: 1418267-50-1
2-acetoxy-2-(3-bromophenyl)acetic acid

: 1418267-24-9
N-(4-carbamimidoylphenyl)-2-hydroxy-2-( 4'-(trifluoromethoxy) biphenyl-3-yl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: toluene / 5 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / acetonitrile; water / 0.5 h / 130 °C / Microwave irradiation

3: trifluoroacetic acid / water; dichloromethane / 4 h / 20 °C

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 3 h / 0 - 20 °C

5: ammonia / methanol / 1.5 h / 20 °C

6: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 760.05 Torr

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; ammonia; hydrogen; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In methanol; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 1418267-51-2
tert-butyl 2-acetoxy-2-(3-bromophenyl)acetate

: 1418267-24-9
N-(4-carbamimidoylphenyl)-2-hydroxy-2-( 4'-(trifluoromethoxy) biphenyl-3-yl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / acetonitrile; water / 0.5 h / 130 °C / Microwave irradiation

2: trifluoroacetic acid / water; dichloromethane / 4 h / 20 °C

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 3 h / 0 - 20 °C

4: ammonia / methanol / 1.5 h / 20 °C

5: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 760.05 Torr

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; ammonia; hydrogen; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In methanol; dichloromethane; water; acetonitrile;