1,1-Dimethylethyl (E)-2-Isopropenyl-5-(1-methyl-3-oxocyclohexyl)-2-pentenoate

Base Information

Chemical Name:1,1-Dimethylethyl (E)-2-Isopropenyl-5-(1-methyl-3-oxocyclohexyl)-2-pentenoate
CAS No.:127488-36-2
Molecular Formula:C₁₉H₃₀O₃
Molecular Weight:306.445
Hs Code.:

Synonyms:1,1-Dimethylethyl (E)-2-Isopropenyl-5-(1-methyl-3-oxocyclohexyl)-2-pentenoate

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Chemical Property of 1,1-Dimethylethyl (E)-2-Isopropenyl-5-(1-methyl-3-oxocyclohexyl)-2-pentenoate

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Technology Process of 1,1-Dimethylethyl (E)-2-Isopropenyl-5-(1-methyl-3-oxocyclohexyl)-2-pentenoate

There total 7 articles about 1,1-Dimethylethyl (E)-2-Isopropenyl-5-(1-methyl-3-oxocyclohexyl)-2-pentenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 127488-41-9
1,1-Dimethylethyl (E)-2-(1-Methylethenyl)-5-(7-methyl-1,4-dioxaspiro<4.5>dec-7-yl)-2-pentenoate

: 127488-36-2
1,1-Dimethylethyl (E)-2-Isopropenyl-5-(1-methyl-3-oxocyclohexyl)-2-pentenoate

Guidance literature:: With hydrogenchloride; for 3h; Ambient temperature;
DOI:10.1021/jo00033a023

Reference yield:

: 1193-18-6
3-methylcyclohexen-2-one

: 127488-36-2
1,1-Dimethylethyl (E)-2-Isopropenyl-5-(1-methyl-3-oxocyclohexyl)-2-pentenoate

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / Cu

2: 78 percent / trimethyl orthoformate, p-TsOH / benzene / 6 h / Ambient temperature

3: 1.) O₃, 2.) dimethyl sulfide / 1.) methanol, -78 deg C, 1 h, 2.) -78 deg C, 3 h, then rt, 4 h

4: 1.) LDA / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, -78 deg C, 2 h, then rt, 8 h

5: 92 percent / aq. HCl / 3 h / Ambient temperature

With hydrogenchloride; dimethylsulfide; toluene-4-sulfonic acid; ozone; lithium diisopropyl amide; trimethyl orthoformate; copper; In benzene;
DOI:10.1021/jo00033a023

Reference yield:

: 5323-87-5
3-Ethoxycyclohex-2-en-1-one

: 127488-36-2
1,1-Dimethylethyl (E)-2-Isopropenyl-5-(1-methyl-3-oxocyclohexyl)-2-pentenoate

Guidance literature:: Multi-step reaction with 6 steps

2: 1.) CuBr / 1.) THF, ether, 0 deg C, 15 min, 2.) THF, -30 deg C, 4 h, then 0 deg C, 0.5 h

3: 78 percent / trimethyl orthoformate, p-TsOH / benzene / 6 h / Ambient temperature

4: 1.) O₃, 2.) dimethyl sulfide / 1.) methanol, -78 deg C, 1 h, 2.) -78 deg C, 3 h, then rt, 4 h

5: 1.) LDA / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, -78 deg C, 2 h, then rt, 8 h

6: 92 percent / aq. HCl / 3 h / Ambient temperature

With hydrogenchloride; dimethylsulfide; toluene-4-sulfonic acid; ozone; copper(I) bromide; lithium diisopropyl amide; trimethyl orthoformate; In benzene;
DOI:10.1021/jo00033a023