1-(3-chlorophenyl)-4-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-2-piperazinone

Base Information

Chemical Name:1-(3-chlorophenyl)-4-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-2-piperazinone
CAS No.:355126-33-9
Molecular Formula:C₂₂H₁₉ClFN₅O
Molecular Weight:423.877
Hs Code.:

Synonyms:1-(3-chlorophenyl)-4-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-2-piperazinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(3-chlorophenyl)-4-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-2-piperazinone

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Technology Process of 1-(3-chlorophenyl)-4-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-2-piperazinone

There total 7 articles about 1-(3-chlorophenyl)-4-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-2-piperazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 183500-94-9
1-(3-chlorophenyl)-2-piperazinone hydrochloride

: 254108-49-1
2-fluoro-4-[(5-formyl-1H-imidazol-1-yl)methyl]benzonitrile

: 355126-33-9
1-(3-chlorophenyl)-4-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-2-piperazinone

Guidance literature:: With 4 A molecular sieve; sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane;
DOI:10.1016/S0960-894X(01)00240-2

Reference yield:

: 254108-49-1
2-fluoro-4-[(5-formyl-1H-imidazol-1-yl)methyl]benzonitrile

: 355126-33-9
1-(3-chlorophenyl)-4-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-2-piperazinone

Guidance literature:: With sodium tris(acetoxy)borohydride; silica gel; In dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 452-74-4
4-bromo-3-fluorotoluene

: 355126-33-9
1-(3-chlorophenyl)-4-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-2-piperazinone

Guidance literature:: Multi-step reaction with 6 steps

1.1: 96 percent / Pd(PPh₃)4 / dimethylformamide / 80 °C

2.1: NBS; benzoyl peroxide / CCl₄ / Heating

3.1: ethyl acetate / 60 °C

3.2: MeOH

4.1: aq. LiOH / tetrahydrofuran

5.1: Py*SO₃; Et₃N / dimethylsulfoxide

6.1: Na(OAc)3BH; 4 Angstroem sieves / 1,2-dichloro-ethane

With lithium hydroxide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 4 A molecular sieve; sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; triethylamine; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; dimethyl sulfoxide; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(01)00240-2