(1S,2S)-1-(1-triphenylmethyl-1H-imidazol-4-yl)-2-cyclopropaneacetic acid

Base Information

Chemical Name:(1S,2S)-1-(1-triphenylmethyl-1H-imidazol-4-yl)-2-cyclopropaneacetic acid
CAS No.:910630-53-4
Molecular Formula:C₂₇H₂₄N₂O₂
Molecular Weight:408.5
Hs Code.:

Synonyms:(1S,2S)-1-(1-triphenylmethyl-1H-imidazol-4-yl)-2-cyclopropaneacetic acid

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Chemical Property of (1S,2S)-1-(1-triphenylmethyl-1H-imidazol-4-yl)-2-cyclopropaneacetic acid

Chemical Property:

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Technology Process of (1S,2S)-1-(1-triphenylmethyl-1H-imidazol-4-yl)-2-cyclopropaneacetic acid

There total 3 articles about (1S,2S)-1-(1-triphenylmethyl-1H-imidazol-4-yl)-2-cyclopropaneacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 524696-17-1
(1S,2S)-2-formylmethyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane

: 910630-53-4
(1S,2S)-1-(1-triphenylmethyl-1H-imidazol-4-yl)-2-cyclopropaneacetic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; at 20 ℃; for 0.5h;
DOI:10.1021/jm0603318

Reference yield:

: 370856-58-9
(1S,2R)-2-formyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane

: 910630-53-4
(1S,2S)-1-(1-triphenylmethyl-1H-imidazol-4-yl)-2-cyclopropaneacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaHMDS / tetrahydrofuran / 0.25 h / 0 °C

1.2: 418 mg / tetrahydrofuran / 3 h / 0 °C

2.1: aq. HCl / acetone; tetrahydrofuran; CH₂Cl₂ / 0 h / 20 °C

3.1: 354 mg / NaClO₂; NaH₂PO₄*2H₂O; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 0.5 h / 20 °C

With hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water; acetone; tert-butyl alcohol; 1.2: Wittig reaction;
DOI:10.1021/jm0603318

Reference yield:

: 524696-16-0
4-[(1S,2R)-2-((Z)-2-Methoxy-vinyl)-cyclopropyl]-1-trityl-1H-imidazole

: 910630-53-4
(1S,2S)-1-(1-triphenylmethyl-1H-imidazol-4-yl)-2-cyclopropaneacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: aq. HCl / acetone; tetrahydrofuran; CH₂Cl₂ / 0 h / 20 °C

2: 354 mg / NaClO₂; NaH₂PO₄*2H₂O; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 0.5 h / 20 °C

With hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In tetrahydrofuran; dichloromethane; water; acetone; tert-butyl alcohol;
DOI:10.1021/jm0603318