9-(3,5-di-O-benzoyl-2-deozy-2-fluoro-β-L-arabinofuranosyl)-2,6-dichloro-9H-purine

Base Information

• Chemical Name: 9-(3,5-di-O-benzoyl-2-deozy-2-fluoro-β-L-arabinofuranosyl)-2,6-dichloro-9H-purine
• CAS No.: 171721-01-0
• Molecular Formula: C₂₄H₁₇Cl₂FN₄O₅
• Molecular Weight: 531.327
• Mol file: 171721-01-0.mol

Synonyms:9-(3,5-di-O-benzoyl-2-deozy-2-fluoro-β-L-arabinofuranosyl)-2,6-dichloro-9H-purine

Chemical Property of 9-(3,5-di-O-benzoyl-2-deozy-2-fluoro-β-L-arabinofuranosyl)-2,6-dichloro-9H-purine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-(3,5-di-O-benzoyl-2-deozy-2-fluoro-β-L-arabinofuranosyl)-2,6-dichloro-9H-purine

There total 1 articles about 9-(3,5-di-O-benzoyl-2-deozy-2-fluoro-β-L-arabinofuranosyl)-2,6-dichloro-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6 dichloropurine (5451-40-1) + 1-bromo-2-deoxy-2-β-fluoro-3,5-di-O-benzoyl-α-L-arabinose (171866-29-8) → 9-(3,5-di-O-benzoyl-2-deozy-2-fluoro-β-L-arabinofuranosyl)-2,6-dichloro-9H-purine (171721-01-0)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) CH₃CN, RT, 30 min, 2.) CH₃CN, RT, 3 h;

DOI:10.1021/jm970233+

Reference yield:

9-(3,5-di-O-benzoyl-2-deozy-2-fluoro-β-L-arabinofuranosyl)-2,6-dichloro-9H-purine (171721-01-0) → C24H21FN6O5 (193754-15-3)

Guidance literature:

Multi-step reaction with 2 steps

1: LiN₃ / aq. ethanol / 0.67 h / Heating

2: H₂ / 10percent Pd/C / ethanol / 2 h / 760 Torr

With lithium azide; hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm970233+

Reference yield:

9-(3,5-di-O-benzoyl-2-deozy-2-fluoro-β-L-arabinofuranosyl)-2,6-dichloro-9H-purine (171721-01-0) → C24H17FN10O5 (193754-14-2)

Guidance literature:

With lithium azide; In ethanol; for 0.666667h; Heating;

DOI:10.1021/jm970233+

upstream raw materials:

2,6 dichloropurine

1-bromo-2-deoxy-2-β-fluoro-3,5-di-O-benzoyl-α-L-arabinose

Downstream raw materials:

C₂₄H₁₇FN₁₀O₅

C₂₄H₂₁FN₆O₅